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A protein phosphatase 2A complex spatially controls plant cell division
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A protein phosphatase 2A complex spatially controls plant cell division
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Journal Article
A protein phosphatase 2A complex spatially controls plant cell division
2013
Overview
In the absence of cell migration, the orientation of cell divisions is crucial for body plan determination in plants. The position of the division plane in plant cells is set up premitotically via a transient cytoskeletal array, the preprophase band, which precisely delineates the cortical plane of division. Here we describe a protein complex that targets protein phosphatase 2A activity to microtubules, regulating the transition from the interphase to the premitotic microtubule array. This complex, which comprises TONNEAU1 and a PP2A heterotrimeric holoenzyme with FASS as regulatory subunit, is recruited to the cytoskeleton via the TONNEAU1-recruiting motif family of proteins. Despite the acentrosomal nature of plant cells, all members of this complex share similarity with animal centrosomal proteins involved in ciliary and centriolar/centrosomal functions, revealing an evolutionary link between the cortical cytoskeleton of plant cells and microtubule organizers in other eukaryotes.
Spatial positioning of the division plane in plant cells is determined premitotically by the preprophase band of microtubules. Spinner
et al.
show that its formation in
Arabidopsis
requires a PP2A complex containing FASS and TON1 which is recruited to cortical microtubules by the TRM protein family.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Alleles
/ Arabidopsis - ultrastructure
/ Arabidopsis Proteins - genetics
/ Arabidopsis Proteins - metabolism
/ Humanities and Social Sciences
/ Microtubule-Associated Proteins - genetics
/ Microtubule-Associated Proteins - metabolism
/ Multiprotein Complexes - metabolism
/ Phosphoprotein Phosphatases - metabolism
/ Prophase
/ Protein Phosphatase 2 - genetics
/ Protein Phosphatase 2 - metabolism
/ Science
