Journal Article

Subacute THYROiditis Related to SARS-CoV-2 VAccine and Covid-19 (THYROVAC Study): A Multicenter Nationwide Study

Batman, Adnan, Bahçecioglu, Adile Begüm, Andac, Burak, Ayas, Görkem, Yilmaz, Merve, Genc, Selin, Çetinarslan, Berrin, Bursa, Nurbanu, Unubol, Mustafa, Selek, Alev, Yorulmaz, Göknur, Yazıcı, Dilek, Ünsal, Yasemin Aydoğan, Dogan, Ozlem, Demir, Tevfik, Demirci, İbrahim, Basmaz, Seda Erem, Çağlayan, Kenan, Ünal, Mehmet Çağrı, Taşkaldıran, Işılay, Özer, Özge, Bahadır, Çiğdem Tura, Ağbaht, Kemal, İpekçi, Süleyman Hilmi, Oğuz, Ayten, Demir, Canan, Polat, Şefika Burçak, Uygur, Meliha Melin, Güven, Mehmet, Erdoğan, Murat Faik, Haydardedeoğlu, Filiz Ekşi, Şener, Selcuk Yusuf, Kalkan, Ahmet Toygar, Çakır, Sezin Doğan, Günay, Yasemin Emur, Alagöl, Faruk, Aydın, Cevdet, Saygılı, Emre Sedar, İmre, Eren, Sezer, Havva, Çakır, Bekir, Şahin, Mustafa, Cantürk, Zeynep, Güler, Bağdagül Yüksel, Omma, Tülay, Mutlu, Ümmü, Kayıhan, Serdar, Uçan, Bekir, Deyneli, Oğuzhan, Eroğlu, Mustafa, İnce, Nurcan, Hepşen, Sema, Üzüm, Ayşe Kubat, Saydam, Başak Özgen, Çelik, Özlem, Kirac, Cem Onur, Pekkolay, Zafer, Calapkulu, Murat, Gürkan, Eren, Topaloğlu, Ömercan, Uğur, Kader, Hacışahinoğulları, Hülya, Cesur, Mustafa, Sözen, Mehmet, Uc, Ziynet Alpha

2023

Overview

Abstract Context The aims of the study are to compare characteristics of subacute thyroiditis (SAT) related to different etiologies, and to identify predictors of recurrence of SAT and incident hypothyroidism. Methods This nationwide, multicenter, retrospective cohort study included 53 endocrinology centers in Turkey. The study participants were divided into either COVID-19–related SAT (Cov-SAT), SARS-CoV-2 vaccine–related SAT (Vac-SAT), or control SAT (Cont-SAT) groups. Results Of the 811 patients, 258 (31.8%) were included in the Vac-SAT group, 98 (12.1%) in the Cov-SAT group, and 455 (56.1%) in the Cont-SAT group. No difference was found between the groups with regard to laboratory and imaging findings. SAT etiology was not an independent predictor of recurrence or hypothyroidism. In the entire cohort, steroid therapy requirement and younger age were statistically significant predictors for SAT recurrence. C-reactive protein measured during SAT onset, female sex, absence of antithyroid peroxidase (TPO) positivity, and absence of steroid therapy were statistically significant predictors of incident (early) hypothyroidism, irrespective of SAT etiology. On the other hand, probable predictors of established hypothyroidism differed from that of incident hypothyroidism. Conclusion Since there is no difference in terms of follow-up parameters and outcomes, COVID-19– and SARS-CoV-2 vaccine–related SAT can be treated and followed up like classic SATs. Recurrence was determined by younger age and steroid therapy requirement. Steroid therapy independently predicts incident hypothyroidism that may sometimes be transient in overall SAT and is also associated with a lower risk of established hypothyroidism.

• Publisher: Oxford University Press
• Subject: C-reactive protein / COVID-19 / COVID-19 - complications / COVID-19 - epidemiology / COVID-19 - prevention & control / COVID-19 vaccines / COVID-19 Vaccines - adverse effects / Endocrinology / Etiology / Female / Humans / Hypothyroidism / Hypothyroidism - complications / Hypothyroidism - etiology / Retrospective Studies / SARS-CoV-2 / Severe acute respiratory syndrome coronavirus 2 / Statistical analysis / Steroids / Thyroiditis / Thyroiditis, Subacute - epidemiology / Thyroiditis, Subacute - etiology / Vaccines