Journal Article

Clopidogrel with Aspirin in Acute Minor Stroke or Transient Ischemic Attack

Xia, Haiqin, Zeng, Jinsheng, Li, Yansheng, Johnston, S. Claiborne, Dong, Qiang, Li, Hao, Liu, Liping, Jia, Jianping, Zhao, Xingquan, Wang, Yilong, Meng, Xia, Xu, Anding, Wang, Zhimin, Cui, Liying, Wang, David, Wang, Chen, Wang, Chunxue, Wang, Yongjun

2013

Overview

In this trial involving patients with minor stroke or transient ischemic attack, treatment with a combination of clopidogrel and aspirin within 24 hours after onset reduced the risk of stroke in the next 90 days, as compared with aspirin alone. Transient ischemic attack (TIA) and acute minor ischemic stroke are common and often lead to disabling events. In China, there are approximately 3 million new strokes every year, and approximately 30% of them are minor ischemic strokes. 1 , 2 The incidence of TIA in China has not been determined, but on the basis of the incidence in other countries, there are probably more than 2 million TIAs annually in China. 3 – 5 The risk of another stroke occurring after a TIA or minor stroke is high, with approximately 10 to 20% of patients having a stroke within 3 months after the index . . .

• Publisher: Massachusetts Medical Society
• Subject: Acute coronary syndromes / Aged / Aspirin / Aspirin - adverse effects / Aspirin - therapeutic use / Biological and medical sciences / Clopidogrel / Disease-Free Survival / Double-Blind Method / Drug therapy / Drug Therapy, Combination / Female / General aspects / Hemorrhage / Hemorrhage - chemically induced / Humans / Ischemia / Ischemic Attack, Transient - drug therapy / Male / Medical sciences / Middle Aged / Motivation / Neurology / Patients / Platelet Aggregation Inhibitors - adverse effects / Platelet Aggregation Inhibitors - therapeutic use / Proportional Hazards Models / Secondary Prevention / Stroke / Stroke - drug therapy / Stroke - prevention & control / Ticlopidine - adverse effects / Ticlopidine - analogs & derivatives / Ticlopidine - therapeutic use / Transient ischemic attack / Vascular diseases and vascular malformations of the nervous system