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Once-Weekly Dalbavancin versus Daily Conventional Therapy for Skin Infection

by Wilcox, Mark , Das, Anita F , Talbot, George H , Boucher, Helen W , Dunne, Michael W , Puttagunta, Sailaja

in Acetamides - administration & dosage / Acetamides - adverse effects / Acute Disease / Adolescent / Adult / Aged / Aged, 80 and over / Anti-Bacterial Agents - administration & dosage / Anti-Bacterial Agents - adverse effects / Antibacterial agents / Antibiotics / Antibiotics. Antiinfectious agents. Antiparasitic agents / Biological and medical sciences / Clinical trials / Diarrhea / Double-Blind Method / Drug Administration Schedule / Drug dosages / Drug resistance / Erythema / Female / Fever / General aspects / Humans / Infusions, Intravenous / Intravenous administration / Linezolid / Male / Medical sciences / Methicillin / Middle Aged / Nausea / Oxazolidinones - administration & dosage / Oxazolidinones - adverse effects / Patients / Pharmacology. Drug treatments / Pruritus / Skin / Skin Diseases, Bacterial - drug therapy / Staphylococcus aureus / Staphylococcus infections / Teicoplanin - administration & dosage / Teicoplanin - adverse effects / Teicoplanin - analogs & derivatives / Vancomycin / Vancomycin - administration & dosage / Vancomycin - adverse effects / Young Adult

2014

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Once-Weekly Dalbavancin versus Daily Conventional Therapy for Skin Infection

by Wilcox, Mark , Das, Anita F , Talbot, George H , Boucher, Helen W , Dunne, Michael W , Puttagunta, Sailaja

2014

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Once-Weekly Dalbavancin versus Daily Conventional Therapy for Skin Infection

by Wilcox, Mark , Das, Anita F , Talbot, George H , Boucher, Helen W , Dunne, Michael W , Puttagunta, Sailaja

2014

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Journal Article

Once-Weekly Dalbavancin versus Daily Conventional Therapy for Skin Infection

Wilcox, Mark,

Das, Anita F,

Talbot, George H,

Boucher, Helen W,

Dunne, Michael W,

Puttagunta, Sailaja

2014

Overview

Treatment of acute bacterial skin infection is becoming more complicated as antimicrobial resistance increases. In this trial of dalbavancin, a lipoglycopeptide with a long half-life, once-weekly dosing was shown to be noninferior to vancomycin–linezolid for treating infection. Acute bacterial skin and skin-structure infections are among the most common reasons for the hospitalization of adults in the United States today. 1 These infections are caused most often by Staphylococcus aureus and streptococci. 2 Methicillin-resistant S. aureus (MRSA) accounts for many of these infections and presents a particular treatment challenge because current therapies are limited by toxicity, resistance, or the lack of an oral formulation. 3 Associated medical costs are substantial. 4 Dalbavancin (Durata Therapeutics) is a lipoglycopeptide antibiotic agent with in vitro and in vivo activity against gram-positive pathogens, including a minimal inhibitory concentration (MIC) required to inhibit the growth of 90% . . .

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Publisher

Massachusetts Medical Society

Subject

Acetamides - administration & dosage

/ Acetamides - adverse effects

/ Acute Disease

/ Adolescent

/ Adult

/ Aged

/ Aged, 80 and over