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Radiotherapy with or without Chemotherapy in Muscle-Invasive Bladder Cancer
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Radiotherapy with or without Chemotherapy in Muscle-Invasive Bladder Cancer
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Journal Article
Radiotherapy with or without Chemotherapy in Muscle-Invasive Bladder Cancer
2012
Overview
Management of muscle-invasive bladder cancer with radiation is associated with a 45% local relapse rate at 2 years. Concurrent treatment with mitomycin C and fluorouracil reduced recurrence to 33% and was not associated with increased late treatment-related toxicity.
Bladder cancer, with more than 385,000 new cases worldwide in 2008,
1
is a major cause of cancer complications. The median age at diagnosis is over 70 years, and since the tumor often is related to smoking, many patients have a substantial number of coexisting illnesses that pose risks for radical surgical approaches. Survival rates are poor for muscle-invasive bladder cancer, with around 45% of patients surviving for 5 years regardless of the type of treatment.
2
–
4
Although surgery is considered the standard therapy, considerable interest in bladder preservation has led to the use of radiotherapy as an alternative, particularly in . . .
Publisher
Massachusetts Medical Society
Subject
/ Aged
/ Antineoplastic Combined Chemotherapy Protocols - adverse effects
/ Antineoplastic Combined Chemotherapy Protocols - therapeutic use
/ Biological and medical sciences
/ Cancer
/ Combined Modality Therapy - adverse effects
/ Dose Fractionation, Radiation
/ Female
/ Fluorouracil - administration & dosage
/ Humans
/ Male
/ Mitomycin - administration & dosage
/ Nephrology. Urinary tract diseases
/ Patients
/ Radiotherapy - adverse effects
/ Survival
/ Tumors of the urinary system
/ Urinary Bladder Neoplasms - drug therapy
/ Urinary Bladder Neoplasms - mortality
/ Urinary Bladder Neoplasms - radiotherapy
/ Urinary system involvement in other diseases. Miscellaneous
