Journal Article

An Inactivated Enterovirus 71 Vaccine in Healthy Children

Cui, Pingfang, Wang, Jingjing, Che, Yanchun, Li, Yanping, Liang, Yan, Wang, Junzhi, Wang, Lichun, Wang, Xuanyi, Zhao, Hongling, Liang, Zhenglun, Sun, Le, Jiang, Zhiwei, Nong, Yi, Liao, Yun, Dong, Chenghong, Pu, Jing, Xie, Zhongping, Guo, Lei, Shi, Haijing, Yang, Erxia, Liu, Jiansheng, Li, Qihan, Mo, Zhaojun, Li, Rongcheng, Na, Ruixiong, Xia, Jielai, Liu, Longding, Jiang, Li, Zhang, Ying, Mao, Qunying, Huang, Teng

2014

Overview

Enterovirus 71 (EV71), a cause of hand, foot, and mouth disease, may be associated with poliomyelitis-like paralysis. In this report from China, a vaccine was shown to significantly decrease EV71-associated illness in children. Epidemics of hand, foot, and mouth disease in children have emerged recently in Asia and have been caused primarily by enterovirus 71 (EV71) and coxsackievirus A16, 1 which typically show two peak epidemic incidences each year, in May and October. 2 – 5 An important clinical concern regarding hand, foot, and mouth disease is central nervous system injury, which occurs during the disease course in some severe cases and may result in a poor outcome. 6 – 11 Infection with the EV71 C4 genotype accounts for 40.1 to 55.4% of cases of hand, foot, and mouth disease, with considerable associated mortality, including thousands of deaths . . .

• Publisher: Massachusetts Medical Society
• Subject: Antibodies, Neutralizing - blood / Antibodies, Viral - blood / Biological and medical sciences / Child, Preschool / Children / China / Double-Blind Method / Double-blind studies / Drug dosages / Enterovirus / Enterovirus A, Human - genetics / Enterovirus A, Human - immunology / Female / Fever / Fever - etiology / General aspects / Genotype & phenotype / Hand, Foot and Mouth Disease - epidemiology / Hand, Foot and Mouth Disease - immunology / Hand, Foot and Mouth Disease - prevention & control / Hand-foot-and-mouth disease / Humans / Immune response / Infant / Injections, Intramuscular / Kaplan-Meier Estimate / Male / Medical research / Medical sciences / Motivation / Seroconversion / Vaccination / Vaccine efficacy / Vaccines / Vaccines, Inactivated / Viral Vaccines - administration & dosage / Viral Vaccines - adverse effects / Viral Vaccines - immunology