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Closure of Patent Foramen Ovale versus Medical Therapy after Cryptogenic Stroke
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Closure of Patent Foramen Ovale versus Medical Therapy after Cryptogenic Stroke
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Journal Article
Closure of Patent Foramen Ovale versus Medical Therapy after Cryptogenic Stroke
2013
Overview
In this study, closure of a patent foramen ovale versus medical therapy alone after cryptogenic stroke was not effective in preventing recurrent stroke. Secondary analyses suggested a possible benefit, but the study did not permit a definitive conclusion.
It is unknown whether closure of a patent foramen ovale is effective in the prevention of recurrent stroke after a cryptogenic ischemic stroke. Observational studies and meta-analyses have suggested that closure is associated with a benefit; however, a randomized trial, Evaluation of the STARFlex Septal Closure System in Patients with a Stroke and/or Transient Ischemic Attack due to Presumed Paradoxical Embolism through a Patent Foramen Ovale (CLOSURE I), failed to show the superiority of closure over medical therapy alone.
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In observational studies, the Amplatzer PFO Occluder has been shown to have advantageous safety features as a closure device.
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Publisher
Massachusetts Medical Society
Subject
/ Aspirin
/ Biological and medical sciences
/ Cardiac Catheterization - adverse effects
/ Congenital heart diseases. Malformations of the aorta, pulmonary vessels and vena cava
/ Embolism - prevention & control
/ Female
/ Fibrinolytic Agents - adverse effects
/ Fibrinolytic Agents - therapeutic use
/ Foramen Ovale, Patent - complications
/ Foramen Ovale, Patent - drug therapy
/ Foramen Ovale, Patent - mortality
/ Foramen Ovale, Patent - therapy
/ Heart
/ Humans
/ Ischemia
/ Male
/ NMR
/ Patients
/ Risk
/ Septal Occluder Device - adverse effects
/ Stroke
/ Stroke - prevention & control
/ Vascular diseases and vascular malformations of the nervous system
/ Warfarin
