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Albumin Replacement in Patients with Severe Sepsis or Septic Shock
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Albumin Replacement in Patients with Severe Sepsis or Septic Shock
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Journal Article
Albumin Replacement in Patients with Severe Sepsis or Septic Shock
2014
Overview
In patients with severe sepsis, albumin replacement in addition to crystalloid administration conferred no benefit, as compared with crystalloids alone, with respect to mortality at 28 or 90 days. Post hoc analysis suggested a possible benefit in patients with septic shock.
For decades, human albumin has been administered to patients to provide adequate oncotic pressure and intravascular volume.
1
In 1998, however, a report from the Cochrane Injuries Group Albumin Reviewers indicated that the administration of albumin may be potentially harmful in critically ill patients, as compared with the administration of crystalloid solutions.
2
Subsequent meta-analyses reported contradictory findings.
3
,
4
To clarify this issue, a large, double-blind, randomized trial (the Saline versus Albumin Fluid Evaluation [SAFE] study)
5
was conducted, in which 4% albumin solution was compared with normal saline as fluid replacement in critically ill patients, with results indicating that albumin administration was . . .
Publisher
Massachusetts Medical Society
Subject
/ Albumin
/ Albumins - administration & dosage
/ Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
/ Biological and medical sciences
/ Emergency and intensive care: infection, septic shock
/ Female
/ Humans
/ Isotonic Solutions - administration & dosage
/ Male
/ Proteins
/ Rehydration Solutions - therapeutic use
/ Sepsis
