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Newborn Bilirubin Screening for Biliary Atresia
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Newborn Bilirubin Screening for Biliary Atresia
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Journal Article
Newborn Bilirubin Screening for Biliary Atresia
2016
Overview
In this preliminary study at four hospitals, newborn screening for biliary atresia with a two-stage measurement of serum bilirubin levels had very high sensitivity and specificity but a low positive predictive value.
To the Editors:
Biliary atresia accounts for approximately 60% of the liver transplantations in infants younger than 1 year of age. These complicated early transplantations can be prevented only with the use of the Kasai hepatoportoenterostomy. The success of the Kasai procedure is varied, but a good outcome is more likely if the operation is performed before 30 to 45 days of life.
1
Unfortunately, in the United States, infants with biliary atresia are usually identified later and the average age at surgery is 60 to 70 days.
2
To address this problem, the American Academy of Pediatrics recently requested more studies . . .
Publisher
Massachusetts Medical Society
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