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Fungal Burden, Early Fungicidal Activity, and Outcome in Cryptococcal Meningitis in Antiretroviral-Naive or Antiretroviral-Experienced Patients Treated with Amphotericin B or Fluconazole
by
Bicanic, Tihana
, Harrison, Thomas
, Rebe, Kevin
, Bekker, Linda-Gail
, Meintjes, Graeme
, Hayes, Madeleine
, Wood, Robin
in
Adult
/ AIDS-Related Opportunistic Infections - drug therapy
/ AIDS-Related Opportunistic Infections - mortality
/ Amphotericin B - therapeutic use
/ Anti-Retroviral Agents - adverse effects
/ Anti-Retroviral Agents - therapeutic use
/ Antiretroviral agents
/ Antiretroviral drugs
/ Antiretrovirals
/ Art therapy
/ Arts
/ Brief Reports
/ Cryptococcal meningitis
/ Cryptococcus
/ Cytokines
/ Dosage
/ Drug therapy
/ Drug Therapy, Combination
/ Female
/ Fluconazole - therapeutic use
/ Fungal infections
/ HIV
/ HIV Infections - complications
/ HIV Infections - drug therapy
/ Human immunodeficiency virus
/ Humans
/ Infectious diseases
/ Male
/ Meningitis
/ Meningitis, Cryptococcal - drug therapy
/ Meningitis, Cryptococcal - mortality
/ Middle Aged
/ Mortality
/ Observational studies
/ Relapse
/ Treatment Outcome
2007
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Fungal Burden, Early Fungicidal Activity, and Outcome in Cryptococcal Meningitis in Antiretroviral-Naive or Antiretroviral-Experienced Patients Treated with Amphotericin B or Fluconazole
by
Bicanic, Tihana
, Harrison, Thomas
, Rebe, Kevin
, Bekker, Linda-Gail
, Meintjes, Graeme
, Hayes, Madeleine
, Wood, Robin
in
Adult
/ AIDS-Related Opportunistic Infections - drug therapy
/ AIDS-Related Opportunistic Infections - mortality
/ Amphotericin B - therapeutic use
/ Anti-Retroviral Agents - adverse effects
/ Anti-Retroviral Agents - therapeutic use
/ Antiretroviral agents
/ Antiretroviral drugs
/ Antiretrovirals
/ Art therapy
/ Arts
/ Brief Reports
/ Cryptococcal meningitis
/ Cryptococcus
/ Cytokines
/ Dosage
/ Drug therapy
/ Drug Therapy, Combination
/ Female
/ Fluconazole - therapeutic use
/ Fungal infections
/ HIV
/ HIV Infections - complications
/ HIV Infections - drug therapy
/ Human immunodeficiency virus
/ Humans
/ Infectious diseases
/ Male
/ Meningitis
/ Meningitis, Cryptococcal - drug therapy
/ Meningitis, Cryptococcal - mortality
/ Middle Aged
/ Mortality
/ Observational studies
/ Relapse
/ Treatment Outcome
2007
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Fungal Burden, Early Fungicidal Activity, and Outcome in Cryptococcal Meningitis in Antiretroviral-Naive or Antiretroviral-Experienced Patients Treated with Amphotericin B or Fluconazole
by
Bicanic, Tihana
, Harrison, Thomas
, Rebe, Kevin
, Bekker, Linda-Gail
, Meintjes, Graeme
, Hayes, Madeleine
, Wood, Robin
in
Adult
/ AIDS-Related Opportunistic Infections - drug therapy
/ AIDS-Related Opportunistic Infections - mortality
/ Amphotericin B - therapeutic use
/ Anti-Retroviral Agents - adverse effects
/ Anti-Retroviral Agents - therapeutic use
/ Antiretroviral agents
/ Antiretroviral drugs
/ Antiretrovirals
/ Art therapy
/ Arts
/ Brief Reports
/ Cryptococcal meningitis
/ Cryptococcus
/ Cytokines
/ Dosage
/ Drug therapy
/ Drug Therapy, Combination
/ Female
/ Fluconazole - therapeutic use
/ Fungal infections
/ HIV
/ HIV Infections - complications
/ HIV Infections - drug therapy
/ Human immunodeficiency virus
/ Humans
/ Infectious diseases
/ Male
/ Meningitis
/ Meningitis, Cryptococcal - drug therapy
/ Meningitis, Cryptococcal - mortality
/ Middle Aged
/ Mortality
/ Observational studies
/ Relapse
/ Treatment Outcome
2007
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Fungal Burden, Early Fungicidal Activity, and Outcome in Cryptococcal Meningitis in Antiretroviral-Naive or Antiretroviral-Experienced Patients Treated with Amphotericin B or Fluconazole
Journal Article
Fungal Burden, Early Fungicidal Activity, and Outcome in Cryptococcal Meningitis in Antiretroviral-Naive or Antiretroviral-Experienced Patients Treated with Amphotericin B or Fluconazole
2007
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Overview
In a prospective observational study of 54 patients with human immunodeficiency virus-associated cryptococcal meningitis, the early fungicidal activity of amphotericin B (1 mg/kg/day) was significantly greater than that of fluconazole (400 mg/day). Compared with antiretroviral therapy-naive patients, patients developing cryptococcal meningitis while already receiving antiretroviral therapy had lower baseline fungal burdens and a longer median duration of survival, but there were no differences observed in fungal clearance, cerebrospinal fluid proinflammatory cytokines, or 10-week mortality.
Publisher
The University of Chicago Press,University of Chicago Press,Oxford University Press
Subject
/ AIDS-Related Opportunistic Infections - drug therapy
/ AIDS-Related Opportunistic Infections - mortality
/ Amphotericin B - therapeutic use
/ Anti-Retroviral Agents - adverse effects
/ Anti-Retroviral Agents - therapeutic use
/ Arts
/ Dosage
/ Female
/ Fluconazole - therapeutic use
/ HIV
/ HIV Infections - complications
/ HIV Infections - drug therapy
/ Human immunodeficiency virus
/ Humans
/ Male
/ Meningitis, Cryptococcal - drug therapy
/ Meningitis, Cryptococcal - mortality
/ Relapse
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