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Vitamin B12 produced by gut bacteria modulates cholinergic signalling
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Journal Article
Vitamin B12 produced by gut bacteria modulates cholinergic signalling
2024
Overview
A growing body of evidence indicates that gut microbiota influence brain function and behaviour. However, the molecular basis of how gut bacteria modulate host nervous system function is largely unknown. Here we show that vitamin B
12
-producing bacteria that colonize the intestine can modulate excitatory cholinergic signalling and behaviour in the host
Caenorhabditis elegans
. Here we demonstrate that vitamin B
12
reduces cholinergic signalling in the nervous system through rewiring of the methionine (Met)/
S
-adenosylmethionine cycle in the intestine. We identify a conserved metabolic crosstalk between the methionine/
S
-adenosylmethionine cycle and the choline-oxidation pathway. In addition, we show that metabolic rewiring of these pathways by vitamin B
12
reduces cholinergic signalling by limiting the availability of free choline required by neurons to synthesize acetylcholine. Our study reveals a gut–brain communication pathway by which enteric bacteria modulate host behaviour and may affect neurological health.
Kang et al. find that vitamin B
12
from gut bacteria modulates host neural function and behaviour in
Caenorhabditis elegans
: vitamin B
12
rewires the methionine/
S
-adenosylmethionine cycle and choline metabolism, impacting free choline levels for neuronal acetylcholine synthesis.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
