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Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with 15O-H2O PET
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Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with 15O-H2O PET
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Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with 15O-H2O PET
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Journal Article
Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with 15O-H2O PET
2014
Overview
Objectives
This study introduces a method to calculate myocardium blood flow (MBF) and coronary flow reserve (CFR) using the relatively low-dose dynamic 320-row multi-detector computed tomography (MDCT), validates the method against
15
O-H
2
O positron-emission tomography (PET) and assesses the CFRs of coronary artery disease (CAD) patients.
Methods
Thirty-two subjects underwent both dynamic CT perfusion (CTP) and PET perfusion imaging at rest and during pharmacological stress. In 12 normal subjects (pilot group), the calculation method for MBF and CFR was established. In the other 13 normal subjects (validation group), MBF and CFR obtained by dynamic CTP and PET were compared. Finally, the CFRs obtained by dynamic CTP and PET were compared between the validation group and CAD patients (
n
= 7).
Results
Correlation between MBF of MDCT and PET was strong (
r
= 0.95,
P
< 0.0001). CFR showed good correlation between dynamic CTP and PET (
r
= 0.67,
P
= 0.0126). CFR
CT
in the CAD group (2.3 ± 0.8) was significantly lower than that in the validation group (5.2 ± 1.8) (
P
= 0.0011).
Conclusions
We established a method for measuring MBF and CFR with the relatively low-dose dynamic MDCT. Lower CFR was well demonstrated in CAD patients by dynamic CTP.
Key Points
•
MBF and CFR can be calculated using dynamic CTP with 320-row MDCT.
•
MBF and CFR showed good correlation between dynamic CTP and PET.
•
Lower CFR was well demonstrated in CAD patients by dynamic CTP.
Publisher
Springer Berlin Heidelberg
Subject
/ Aged
/ Cardiac
/ Coronary Artery Disease - diagnosis
/ Coronary Artery Disease - physiopathology
/ Coronary Circulation - physiology
/ Female
/ Humans
/ Image Processing, Computer-Assisted
/ Imaging
/ Male
/ Medicine
/ Multidetector Computed Tomography - methods
/ Positron-Emission Tomography - methods
