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Effect of a Short-Term Intervention with Lactobacillus salivarius Probiotic on Early Childhood Caries—An Open Label Randomized Controlled Trial
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Effect of a Short-Term Intervention with Lactobacillus salivarius Probiotic on Early Childhood Caries—An Open Label Randomized Controlled Trial
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Effect of a Short-Term Intervention with Lactobacillus salivarius Probiotic on Early Childhood Caries—An Open Label Randomized Controlled Trial
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Journal Article
Effect of a Short-Term Intervention with Lactobacillus salivarius Probiotic on Early Childhood Caries—An Open Label Randomized Controlled Trial
2022
Overview
ECC is a significant therapeutic and social problem and a global burden on public health. The aim of this clinical trial was to test whether a 2-week daily consumption of chewing tablets containing thermally inactivated L. salivarius reduces the 12-month caries increment compared to the control group. The investigation was a single-center, randomized, controlled open-label, blinded end-point evaluation trial in two parallel groups. At baseline, 140 generally healthy children between 3 and 6 years of age with or without ECC were randomly assigned to the probiotic test group (n = 70) or to the treatment as the usual control group (n = 70). The primary outcome measure was the 1-year increment in caries incidence and prevalence. Secondary endpoints assessed were the initial, cavitated and obvious dentinal caries increment as well as the measurement of dental plaque accumulation, as an indicator of the ECC risk. Data were collected through the clinical assessment of the children’s caries (dmft and ICDAS II) and oral hygiene status (DI-S of OHI-S index). Caries incidence and prevalence were statistically significantly lower in the probiotic group versus the control group (p < 0.001 and p = 0.0075). The initial and final mean OHI-S scores in the probiotic group did not show any significant differences. In conclusion, the regular short-term intake of probiotics may reduce caries development. Our findings suggest that self-administered probiotic therapy may provide a good complement to increase the effectiveness of individual preventive home care in preschool children. This is the first clinical study evaluating the effect of a short-term probiotic intervention on reducing early childhood caries with 12 months of follow-up.
Publisher
MDPI AG,MDPI
