Journal Article

Toxicity, uptake, and accumulation of nano and bulk cerium oxide particles in Artemia salina

Rajamani Sekar, Suresh Kumar, Madurantakam Royam, Madhav, Natarajan, Chandrasekaran, Sugantharaj David, Einstein Mariya David, Jalaja Soman, Swathy, Manivannan, Bhuvaneshwari, Mukherjee, Amitava

2017

Overview

Although the toxicological impact of metal oxide nanoparticles has been studied for the last few decades on aquatic organisms, the exact mechanism of action is still unclear. The fate, behavior, and biological activity of nanoparticles are dependent on physicochemical factors like size, shape, surface area, and stability in the medium. This study deals with the effect of nano and bulk CeO 2 particles on marine microcrustacean, Artemia salina . The primary size was found to be 15 ± 3.5 and 582 ± 50 nm for nano and bulk CeO 2 (TEM), respectively. The colloidal stability and sedimentation assays showed rapid aggregation of bulk particles in seawater. Both the sizes of CeO 2 particles inhibited the hatching rate of brine shrimp cyst. Nano CeO 2 was found to be more toxic to A. salina (48 h LC 50 38.0 mg/L) when compared to bulk CeO 2 (48 h LC 50 92.2 mg/L). Nano CeO 2 -treated A. salina showed higher oxidative stress (ROS) than those treated with the bulk form. The reduction in the antioxidant activity indicated an increase in oxidative stress in the cells. Higher acetylcholinesterase activity (AChE) was observed upon exposure to nano and bulk CeO 2 particles. The uptake and accumulation of CeO 2 particles were increased with respect to the concentration and particle size. Thus, the above results revealed that nano CeO 2 was more lethal to A. salina as compared to bulk particles.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Accumulation / Acetylcholinesterase / Animals / antioxidant activity / Antioxidants / Aquatic organisms / Aquatic Pollution / Artemia / Artemia - drug effects / Artemia - metabolism / Artemia salina / Atmospheric Protection/Air Quality Control/Air Pollution / Biological activity / ceric oxide / Cerium / Cerium - metabolism / Cerium - toxicity / Cerium oxides / Earth and Environmental Science / Ecotoxicology / Environment / Environmental Chemistry / Environmental Health / Environmental science / enzyme activity / Hatching / lethal concentration 50 / Marine crustaceans / mechanism of action / Metal Nanoparticles - toxicity / Metal oxides / Nanoparticles / Oxidative stress / Particle Size / Reactive oxygen species / Research Article / Seawater / Sedimentation / Shellfish / Stability / surface area / Toxicity / Toxicology / transmission electron microscopy / Waste Water Technology / Water Management / Water Pollutants, Chemical - metabolism / Water Pollutants, Chemical - toxicity / Water Pollution Control