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Molecular mechanism of strigolactone perception by DWARF14
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Journal Article
Molecular mechanism of strigolactone perception by DWARF14
2013
Overview
Strigolactones (SLs) are phytohormones that inhibit shoot branching and function in the rhizospheric communication with symbiotic fungi and parasitic weeds. An α/β-hydrolase protein, DWARF14 (D14), has been recognized to be an essential component of plant SL signalling, although its precise function remains unknown. Here we present the SL-dependent interaction of D14 with a gibberellin signalling repressor SLR1 and a possible mechanism of phytohormone perception in D14-mediated SL signalling. D14 functions as a cleavage enzyme of SLs, and the cleavage reaction induces the interaction with SLR1. The crystal structure of D14 shows that 5-hydroxy-3-methylbutenolide (D-OH), which is a reaction product of SLs, is trapped in the catalytic cavity of D14 to form an altered surface. The D14 residues recognizing D-OH are critical for the SL-dependent D14−SLR1 interaction. These results provide new insight into crosstalk between gibberellin and SL signalling pathways.
Both strigolactone and DELLA plant signalling pathways have a role in shoot branching. In this study, Nakamura
et al.
show that DWARF14 cleaves strigolactones creating a binding surface for the DELLA protein SLR1, thereby providing a mechanism for pathway crosstalk.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
4-Butyrolactone - analogs & derivatives
/ 4-Butyrolactone - metabolism
/ Escherichia coli - metabolism
/ Gene Expression Regulation, Plant
/ Humanities and Social Sciences
/ Plant Growth Regulators - chemistry
/ Plant Growth Regulators - metabolism
/ Plants, Genetically Modified
/ Recombinant Proteins - chemistry
/ Recombinant Proteins - genetics
/ Recombinant Proteins - metabolism
/ Science
