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Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection
by
Boué Vanina
, Grasset Sophie
, Reynes Jacques
, Graf Christelle
, Alizon Samuel
, Selinger, Christian
, Jacobs, Nathalie
, Groc Soraya
, Murall, Carmen Lia
, Rahmoun Massilva
, Bernat, Claire
, Hirtz Christophe
, Bonneau Marine
in
Cervical cancer
/ Human papillomavirus
/ Infections
/ Inflammation
/ Interleukin 12
/ Macrophages
/ Papillomaviridae
/ Statistical analysis
2021
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Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection
by
Boué Vanina
, Grasset Sophie
, Reynes Jacques
, Graf Christelle
, Alizon Samuel
, Selinger, Christian
, Jacobs, Nathalie
, Groc Soraya
, Murall, Carmen Lia
, Rahmoun Massilva
, Bernat, Claire
, Hirtz Christophe
, Bonneau Marine
in
Cervical cancer
/ Human papillomavirus
/ Infections
/ Inflammation
/ Interleukin 12
/ Macrophages
/ Papillomaviridae
/ Statistical analysis
2021
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Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection
by
Boué Vanina
, Grasset Sophie
, Reynes Jacques
, Graf Christelle
, Alizon Samuel
, Selinger, Christian
, Jacobs, Nathalie
, Groc Soraya
, Murall, Carmen Lia
, Rahmoun Massilva
, Bernat, Claire
, Hirtz Christophe
, Bonneau Marine
in
Cervical cancer
/ Human papillomavirus
/ Infections
/ Inflammation
/ Interleukin 12
/ Macrophages
/ Papillomaviridae
/ Statistical analysis
2021
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Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection
Journal Article
Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection
2021
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Overview
Human papillomaviruses (HPVs) are oncogenic viruses causing most cervical cancers. Highly prevalent in young, sexually active women, only a minority of HPV infections persist. To better characterize the immuno-modulatory impact of early HPV infections, we measured changes in a panel of 20 cytokines in cervicovaginal samples collected from young women who were tested for HPV and self-reported for genital inflammation and infection symptoms. Multi-factor statistical analyses revealed that increased IL-1Alpha and IL-12/IL-23p40 concentrations were associated with HPV infection and that macrophage inflammatory proteins were associated in particular with high-risk HPV infections. ClinicalTrials.gov identifier NCT02946346
Publisher
Springer Nature B.V
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