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Helicobacter pylori CagA promotes Snail-mediated epithelial–mesenchymal transition by reducing GSK-3 activity
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Helicobacter pylori CagA promotes Snail-mediated epithelial–mesenchymal transition by reducing GSK-3 activity
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Journal Article
Helicobacter pylori CagA promotes Snail-mediated epithelial–mesenchymal transition by reducing GSK-3 activity
2014
Overview
Cytotoxin-associated gene A (CagA) is an oncoprotein and a major virulence factor of
H. pylori
. CagA is delivered into gastric epithelial cells via a type IV secretion system and causes cellular transformation. The loss of epithelial adhesion that accompanies the epithelial–mesenchymal transition (EMT) is a hallmark of gastric cancer. Although CagA is a causal factor in gastric cancer, the link between CagA and the associated EMT has not been elucidated. Here, we show that CagA induces the EMT by stabilizing Snail, a transcriptional repressor of E-cadherin expression. Mechanistically we show that CagA binds GSK-3 in a manner similar to Axin and causes it to shift to an insoluble fraction, resulting in reduced GSK-3 activity. We also find that the level of Snail protein is increased in
H. pylori
infected epithelium in clinical samples. These results suggest that
H. pylori
CagA acts as a pathogenic scaffold protein that induces a Snail-mediated EMT via the depletion of GSK-3.
Gastric cancer is associated with
H. pylori
infection and these tumours frequently show features of epithelial–mesenchymal transition (EMT). Here, the authors show that the
H. pylori
virulence protein, CagA, reduces the activity of GSK3b, which leads to the stabilization of Snail, a protein that induces EMT.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/95
/ Antigens, Bacterial - physiology
/ Bacterial Proteins - physiology
/ Biopsy
/ Down-Regulation - physiology
/ Epithelial Cells - metabolism
/ Epithelial Cells - pathology
/ Epithelial-Mesenchymal Transition - physiology
/ Glycogen Synthase Kinase 3 - metabolism
/ Helicobacter pylori - physiology
/ Humanities and Social Sciences
/ Humans
/ Science
/ Signal Transduction - physiology
/ Snail Family Transcription Factors
/ Stomach Neoplasms - metabolism
