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Association of a functional BDNF polymorphism and anxiety-related personality traits
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Association of a functional BDNF polymorphism and anxiety-related personality traits
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Association of a functional BDNF polymorphism and anxiety-related personality traits
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Journal Article
Association of a functional BDNF polymorphism and anxiety-related personality traits
2005
Overview
Converging lines of evidence point to brain-derived neurotrophic factor (BDNF) as a factor in the pathophysiology of depression. Recently, it was shown that the Val allele of the BDNF Val66Met substitution polymorphism showed a significant association with higher mean neuroticism scores of the NEO-Five Factor Inventory (NEO-FFI) in healthy subjects, and previous studies suggested the Val allele to be increased in bipolar disorder families. The association to anxiety-related traits has not been investigated so far.
We tested a total of 343 unrelated subjects of German descent (171 male, 172 female, age: 39.0+/-14.6 years) who were carefully screened for psychiatric health. The self-ratable State-Trait Anxiety Inventory (STAI), which allows anxiety to be quantified as a comparatively stable personality trait, and the NEO-Five Factor Inventory (NEO-FFI) was applied.
In the trait-related anxiety score, a significant (F=3.2, df=2, p<0.042) effect of the genotype was observed with higher levels of trait anxiety in Val/Val (35.0+/-7.4) compared to Val/Met (33.4+/-6.5) and Met/Met (32.0+/-4.6) genotypes. The NEO neuroticism scores were also higher in Val/Val (29.5+/-7.0) than in Val/Met (28.4+/-6.5) or Met/Met (26.8+/-5.8) genotype, but not at a significant rate.
Our findings support the hypothesis that anxiety- and depression-related personality traits are associated with the BDNF polymorphism although the explained variance is low.
Publisher
Springer,Springer Nature B.V
Subject
/ Adult and adolescent clinical studies
/ Anxiety
/ Anxiety Disorders - genetics
/ Biological and medical sciences
/ Brain-Derived Neurotrophic Factor - genetics
/ European Continental Ancestry Group
/ Female
/ Genotype
/ Humans
/ Male
/ Polymorphism, Single Nucleotide
/ Psychiatric Status Rating Scales
