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Outcomes and patterns of care of patients with locally advanced oropharyngeal carcinoma treated in the early 21st century
by
Sturgis, Erich M
, Rosenthal, David I
, Glisson, Bonnie S
, Kies, Merrill S
, Gunn, Gary B
, Morrison, William H
, Frank, Steven J
, Beadle, Beth M
, Garden, Adam S
, Ang, K Kian
, Weber, Randal S
in
Adult
/ Aged
/ Aged, 80 and over
/ Biomedical and Life Sciences
/ Biomedicine
/ Cancer Research
/ Cancer therapies
/ Carcinoma, Squamous Cell - mortality
/ Carcinoma, Squamous Cell - secondary
/ Carcinoma, Squamous Cell - therapy
/ Chemoradiation
/ Chemotherapy
/ Clinical Trials, Phase II as Topic
/ Clinical Trials, Phase III as Topic
/ Colleges & universities
/ Combined Modality Therapy
/ Disease control
/ Disease-Free Survival
/ Epidemiology
/ Family medical history
/ FDA approval
/ Female
/ Follow-Up Studies
/ Head & neck cancer
/ History, 21st Century
/ Hospitals
/ Human papillomavirus
/ Humans
/ Imaging
/ IMRT
/ Male
/ Middle Aged
/ Multivariate analysis
/ Neoplasm Recurrence, Local - mortality
/ Neoplasm Recurrence, Local - pathology
/ Neoplasm Recurrence, Local - therapy
/ Neoplasm Staging
/ Oncology
/ Oropharyngeal cancer
/ Oropharyngeal Neoplasms - mortality
/ Oropharyngeal Neoplasms - pathology
/ Oropharyngeal Neoplasms - therapy
/ Patients
/ Prognosis
/ Radiation
/ Radiology
/ Radiotherapy
/ Squamous cell
/ Survival Rate
/ Treatment Outcome
2013
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Outcomes and patterns of care of patients with locally advanced oropharyngeal carcinoma treated in the early 21st century
by
Sturgis, Erich M
, Rosenthal, David I
, Glisson, Bonnie S
, Kies, Merrill S
, Gunn, Gary B
, Morrison, William H
, Frank, Steven J
, Beadle, Beth M
, Garden, Adam S
, Ang, K Kian
, Weber, Randal S
in
Adult
/ Aged
/ Aged, 80 and over
/ Biomedical and Life Sciences
/ Biomedicine
/ Cancer Research
/ Cancer therapies
/ Carcinoma, Squamous Cell - mortality
/ Carcinoma, Squamous Cell - secondary
/ Carcinoma, Squamous Cell - therapy
/ Chemoradiation
/ Chemotherapy
/ Clinical Trials, Phase II as Topic
/ Clinical Trials, Phase III as Topic
/ Colleges & universities
/ Combined Modality Therapy
/ Disease control
/ Disease-Free Survival
/ Epidemiology
/ Family medical history
/ FDA approval
/ Female
/ Follow-Up Studies
/ Head & neck cancer
/ History, 21st Century
/ Hospitals
/ Human papillomavirus
/ Humans
/ Imaging
/ IMRT
/ Male
/ Middle Aged
/ Multivariate analysis
/ Neoplasm Recurrence, Local - mortality
/ Neoplasm Recurrence, Local - pathology
/ Neoplasm Recurrence, Local - therapy
/ Neoplasm Staging
/ Oncology
/ Oropharyngeal cancer
/ Oropharyngeal Neoplasms - mortality
/ Oropharyngeal Neoplasms - pathology
/ Oropharyngeal Neoplasms - therapy
/ Patients
/ Prognosis
/ Radiation
/ Radiology
/ Radiotherapy
/ Squamous cell
/ Survival Rate
/ Treatment Outcome
2013
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Outcomes and patterns of care of patients with locally advanced oropharyngeal carcinoma treated in the early 21st century
by
Sturgis, Erich M
, Rosenthal, David I
, Glisson, Bonnie S
, Kies, Merrill S
, Gunn, Gary B
, Morrison, William H
, Frank, Steven J
, Beadle, Beth M
, Garden, Adam S
, Ang, K Kian
, Weber, Randal S
in
Adult
/ Aged
/ Aged, 80 and over
/ Biomedical and Life Sciences
/ Biomedicine
/ Cancer Research
/ Cancer therapies
/ Carcinoma, Squamous Cell - mortality
/ Carcinoma, Squamous Cell - secondary
/ Carcinoma, Squamous Cell - therapy
/ Chemoradiation
/ Chemotherapy
/ Clinical Trials, Phase II as Topic
/ Clinical Trials, Phase III as Topic
/ Colleges & universities
/ Combined Modality Therapy
/ Disease control
/ Disease-Free Survival
/ Epidemiology
/ Family medical history
/ FDA approval
/ Female
/ Follow-Up Studies
/ Head & neck cancer
/ History, 21st Century
/ Hospitals
/ Human papillomavirus
/ Humans
/ Imaging
/ IMRT
/ Male
/ Middle Aged
/ Multivariate analysis
/ Neoplasm Recurrence, Local - mortality
/ Neoplasm Recurrence, Local - pathology
/ Neoplasm Recurrence, Local - therapy
/ Neoplasm Staging
/ Oncology
/ Oropharyngeal cancer
/ Oropharyngeal Neoplasms - mortality
/ Oropharyngeal Neoplasms - pathology
/ Oropharyngeal Neoplasms - therapy
/ Patients
/ Prognosis
/ Radiation
/ Radiology
/ Radiotherapy
/ Squamous cell
/ Survival Rate
/ Treatment Outcome
2013
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Outcomes and patterns of care of patients with locally advanced oropharyngeal carcinoma treated in the early 21st century
Journal Article
Outcomes and patterns of care of patients with locally advanced oropharyngeal carcinoma treated in the early 21st century
2013
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Overview
Background
We performed this study to assess outcomes of patients with oropharyngeal cancer treated with modern therapy approaches.
Methods
Demographics, treatments and outcomes of patients diagnosed with Stage 3- 4B squamous carcinoma of the oropharynx, between 2000 – 2007 were tabulated and analyzed.
Results
The cohort consisted of 1046 patients. The 5- year actuarial overall survival, recurrence-free survival and local-regional control rates for the entire cohort were 78%, 77% and 87% respectively. More advanced disease, increasing T-stage and smoking were associated with higher rates of local-regional recurrence and poorer survival.
Conclusions
Patients with locally advanced oropharyngeal cancer have a relatively high survival rate. Patients’ demographics and primary tumor volume were very influential on these favorable outcomes. In particular, patients with small primary tumors did very well even when treatment was not intensified with the addition of chemotherapy.
Publisher
BioMed Central,Springer Nature B.V,BMC
Subject
/ Aged
/ Biomedical and Life Sciences
/ Carcinoma, Squamous Cell - mortality
/ Carcinoma, Squamous Cell - secondary
/ Carcinoma, Squamous Cell - therapy
/ Clinical Trials, Phase II as Topic
/ Clinical Trials, Phase III as Topic
/ Female
/ Humans
/ Imaging
/ IMRT
/ Male
/ Neoplasm Recurrence, Local - mortality
/ Neoplasm Recurrence, Local - pathology
/ Neoplasm Recurrence, Local - therapy
/ Oncology
/ Oropharyngeal Neoplasms - mortality
/ Oropharyngeal Neoplasms - pathology
/ Oropharyngeal Neoplasms - therapy
/ Patients
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