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Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

by Glynn, Robert J , Kobalava, Zhanna , Lorenzatti, Alberto , Fonseca, Francisco , Ballantyne, Christie , Troquay, Roland P.T , Anker, Stefan D , Rossi, Paulo R.F , Kastelein, John J.P , Genest, Jacques , Nicolau, Jose , Everett, Brendan M , Ridker, Paul M , Thuren, Tom , Shimokawa, Hiroaki , Chang, William H , Pais, Prem , Cifkova, Renata , Pella, Daniel , Koenig, Wolfgang , Flather, Marcus , Libby, Peter , Forster, Tamas , Vida-Simiti, Luminita , MacFadyen, Jean G , Cornel, Jan H , Ogawa, Hisao , Dellborg, Mikael

in Aged / Angina / Angina pectoris / Anti-Inflammatory Agents - administration & dosage / Anti-Inflammatory Agents - adverse effects / Antibodies, Monoclonal - administration & dosage / Antibodies, Monoclonal - adverse effects / Arteriosclerosis / Atherosclerosis / Atherosclerosis - blood / Atherosclerosis - drug therapy / C-reactive protein / C-Reactive Protein - metabolism / Cardiovascular disease / Cardiovascular diseases / Cardiovascular Diseases - epidemiology / Cardiovascular Diseases - mortality / Cerebral infarction / Cholesterol / Clinical Medicine / Clinical trials / Cytokines / Disease prevention / Dose-Response Relationship, Drug / Double-Blind Method / Double-blind studies / Drug dosages / Drug therapy / Female / Health risk assessment / Heart attacks / Humans / Incidence / Infection - etiology / Inflammation / Innate immunity / Interleukin-1beta - antagonists & inhibitors / Interleukin-1beta - immunology / Klinisk medicin / Lipids - blood / Male / Middle Aged / Monoclonal antibodies / Myocardial infarction / Myocardial Infarction - drug therapy / Myocardial Infarction - prevention & control / Neutropenia - chemically induced / Proteins / Secondary Prevention / Stroke / Stroke - prevention & control / Thrombosis

2017

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Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

2017

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2017

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Journal Article

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Glynn, Robert J,

Kobalava, Zhanna,

Lorenzatti, Alberto,

Fonseca, Francisco,

Ballantyne, Christie,

Troquay, Roland P.T,

Anker, Stefan D,

Rossi, Paulo R.F,

Kastelein, John J.P,

Genest, Jacques,

Nicolau, Jose,

Everett, Brendan M,

Ridker, Paul M,

Thuren, Tom,

Shimokawa, Hiroaki,

Chang, William H,

Pais, Prem,

Cifkova, Renata,

Pella, Daniel,

Koenig, Wolfgang,

Flather, Marcus,

Libby, Peter,

Forster, Tamas,

Vida-Simiti, Luminita,

MacFadyen, Jean G,

Cornel, Jan H,

Ogawa, Hisao,

Dellborg, Mikael

2017

Overview

Patients with myocardial infarction and a high-sensitivity CRP level of 2 mg or more per liter were assigned to one of three canakinumab doses or placebo. The 150-mg dose, but not the 50-mg or 300-mg dose, led to a lower incidence of recurrent cardiovascular events.

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Publisher

Massachusetts Medical Society

Subject

Aged

/ Angina

/ Angina pectoris

/ Anti-Inflammatory Agents - administration & dosage

/ Anti-Inflammatory Agents - adverse effects

/ Antibodies, Monoclonal - administration & dosage

/ Antibodies, Monoclonal - adverse effects