Journal Article

Therapeutic Use of Cytokines to Modulate Phagocyte Function for the Treatment of Infectious Diseases: Current Status of Granulocyte Colony-Stimulating Factor, Granulocyte-Macrophage Colony-Stimulating Factor, Macrophage Colony-Stimulating Factor, and Interferon-γ

Liles, W. Conrad, Hübel, Kai, Dale, David C.

2002

Overview

The innate immune system represents the initial arm of host defense against pathogenic bacteria, fungi, and parasites. Neutrophils, monocytes, and tissue-based macrophages are major cellular components of this system. The potential ability to augment activity of the innate immune system has increased dramatically during the past 2 decades, with the discovery and development of cytokines. Four cytokines, namely granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), and interferon (IFN)-γ, have received increasing attention as potential adjunctive agents for the treatment of infectious diseases. In various animal models of infection, therapeutic administration of each of the 4 cytokines has been shown to enhance pathogen eradication and to decrease morbidity and/or mortality. However, variable therapeutic efficacy has been reported in clinical trials conducted to date. This review summarizes the current status of the use of G-CSF, GM-CSF, M-CSF, and IFN-γ in the treatment of infectious diseases.

• Publisher: The University of Chicago Press,University of Chicago Press
• Subject: Analysis of the immune response. Humoral and cellular immunity / Animals / Biological and medical sciences / Blood / Chills - etiology / Clinical Trials as Topic / Colony stimulating factors / Communicable Diseases - immunology / Communicable Diseases - therapy / Cytokines / Disease Models, Animal / Fever - etiology / Fundamental and applied biological sciences. Psychology / Fundamental immunology / General aspects / Granulocyte Colony-Stimulating Factor - adverse effects / Granulocyte Colony-Stimulating Factor - therapeutic use / Granulocyte-Macrophage Colony-Stimulating Factor - adverse effects / Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use / Granulocytes / Headache - etiology / Health care administration / Human infectious diseases. Experimental studies and models / Humans / Immunobiology / Infections / Infectious diseases / Interferon-gamma - therapeutic use / Macrophage Colony-Stimulating Factor - adverse effects / Macrophage Colony-Stimulating Factor - therapeutic use / Macrophages / Medical sciences / Neutropenia / Neutrophils / Organs and cells involved in the immune response / Pain - etiology / Phagocytes - drug effects / Phagocytes - immunology / Review / Stem cells / Thrombocytopenia - etiology