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Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A11:01
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Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A11:01
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Journal Article
Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A11:01
2019
Overview
Our understanding of the conformational and electrostatic determinants that underlie targeting of human leukocyte antigens (HLA) by anti-HLA alloantibodies is principally based upon in silico modelling. Here we provide a biochemical/biophysical and functional characterization of a human monoclonal alloantibody specific for a common HLA type, HLA-A*11:01. We present a 2.4 Å resolution map of the binding interface of this antibody on HLA-A*11:01 and compare the structural determinants with those utilized by T-cell receptor (TCR), killer-cell immunoglobulin-like receptor (KIR) and CD8 on the same molecule. These data provide a mechanistic insight into the paratope−epitope relationship between an alloantibody and its target HLA molecule in a biological context where other immune receptors are concomitantly engaged. This has important implications for our interpretation of serologic binding patterns of anti-HLA antibodies in sensitized individuals and thus, for the biology of human alloresponses.
Anti-human leukocyte antigen (HLA) antibodies are important mediators of alloresponses, but structural insights on antibody:HLA interaction are still lacking. Here the authors provide a 2.4 Å structure of antibody:HLA complex, and also analyse HLA features important for other HLA-interacting molecules, to enhance our understanding of alloimmunity.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/31
/ 82/80
/ 82/81
/ Antibodies, Monoclonal - chemistry
/ Antibodies, Monoclonal - genetics
/ Antibodies, Monoclonal - metabolism
/ Antigen-Antibody Complex - chemistry
/ Antigen-Antibody Complex - genetics
/ Antigen-Antibody Complex - metabolism
/ Antigens
/ Binding
/ Binding Sites, Antibody - genetics
/ Epitopes
/ HLA-A11 Antigen - metabolism
/ Humanities and Social Sciences
/ Humans
/ Immunoglobulin G - chemistry
/ Immunoglobulin G - metabolism
/ Killer cell immunoglobulin-like receptors
/ Science
