Journal Article

Metalloproteinases and Their Inhibitors in Patients with Inguinal Hernia

Isik, Arda, Fırat, Deniz, Aydın, Merve, Peker, Kemal, Gursul, Cebrail, Yılmaz, İsmayil

2017

Overview

Aim The aim of this prospective study is to investigate if there is a relationship between inguinal hernia, matrix metalloproteinases (MMPs), and tissue inhibitors of metalloproteinases (TIMPs). Materials and methods This case control study was performed on patients admitted to the general surgery department of Erzincan University Hospital. Four groups were created: control, indirect hernia, direct hernia, and bilateral hernia. All groups were comprised of 11 patients. Serum and tissue levels of MMP-1, MMP-2, MMP-9, MMP-13, TIMP-1, TIMP-2, TIMP-3, and hydroxyproline were evaluated. Results MMPs values were significantly high at hernia groups, especially at bilateral hernia group ( p  < 0.05), whereas TIMPs values were significantly low at bilateral hernia group ( p  < 0.05). MMPs values were increasing at hernia groups in an order as control, indirect, direct, and bilateral. TIMPs values were decreasing at hernia groups in an order as control, indirect, direct, and bilateral. Conclusion Increased levels of MMP-1-2-9-13 and decreased levels of TIMP-1-2-3 may have played role in the formation of inguinal hernia. Hernia is not only a local defect, but a reflection of systemic disease. This is even more significant for bilateral hernias.

• Publisher: Springer International Publishing,John Wiley & Sons, Inc
• Subject: Abdominal Aortic Aneurysm / Abdominal Surgery / Adult / Cardiac Surgery / Case-Control Studies / Female / General Surgery / Hernia, Inguinal - blood / Hernia, Inguinal - metabolism / Humans / Hydroxyproline - blood / Hydroxyproline - metabolism / Incisional Hernia / Inguinal Hernia / Male / Matrix Metalloproteinase 1 - blood / Matrix Metalloproteinase 1 - metabolism / Matrix Metalloproteinase 13 - blood / Matrix Metalloproteinase 13 - metabolism / Matrix Metalloproteinase 2 - blood / Matrix Metalloproteinase 2 - metabolism / Matrix Metalloproteinase 9 - blood / Matrix Metalloproteinase 9 - metabolism / Matrix Metalloproteinases - blood / Matrix Metalloproteinases - metabolism / Medicine / Medicine & Public Health / Middle Aged / Original Scientific Report / Prospective Studies / Surgery / Thoracic Surgery / Tissue Inhibitor of Metalloproteinase-1 - blood / Tissue Inhibitor of Metalloproteinase-1 - metabolism / Tissue Inhibitor of Metalloproteinase-2 - blood / Tissue Inhibitor of Metalloproteinase-2 - metabolism / Tissue Inhibitor of Metalloproteinase-3 - blood / Tissue Inhibitor of Metalloproteinase-3 - metabolism / Tissue Inhibitor of Metalloproteinases - blood / Tissue Inhibitor of Metalloproteinases - metabolism / Varicocele / Vascular Surgery