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Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma

by Corren, Jonathan , Chupp, Geoffrey , Israel, Elliot , Menzies-Gow, Andrew , Kaur, Primal , Almqvist, Gun , Bowen, Karin , Colice, Gene , Bourdin, Arnaud , Wechsler, Michael E , Ponnarambil, Sandhia , Hellqvist, Åsa , Griffiths, Janet M , Brightling, Christopher E

in Adolescent / Adult / Adverse events / Age / Aged / Aged, 80 and over / Airway management / Allergology / Anti-Asthmatic Agents - adverse effects / Anti-Asthmatic Agents - therapeutic use / Antibodies, Monoclonal, Humanized - adverse effects / Antibodies, Monoclonal, Humanized - therapeutic use / Asthma / Asthma - drug therapy / Biomarkers / Child / Cytokines / Double-Blind Method / Hospitalization / Human health and pathology / Humans / Immunology / Immunotherapy / Inflammation / Informed consent / Injections, Subcutaneous / Leukocytes (eosinophilic) / Life Sciences / Middle Aged / Monoclonal antibodies / Patients / Placebos / Pulmonology and respiratory tract / Quality of Life / Questionnaires / Respiratory function / Statistical analysis / Teenagers / Thymic stromal lymphopoietin / Thymus / Young Adult

2021

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Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma

2021

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Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma

2021

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Journal Article

Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma

Corren, Jonathan,

Chupp, Geoffrey,

Israel, Elliot,

Menzies-Gow, Andrew,

Kaur, Primal,

Almqvist, Gun,

Bowen, Karin,

Colice, Gene,

Bourdin, Arnaud,

Wechsler, Michael E,

Ponnarambil, Sandhia,

Hellqvist, Åsa,

Griffiths, Janet M,

Brightling, Christopher E

2021

Overview

Tezepelumab is a monoclonal antibody that blocks thymic stromal lymphopoietin, an epithelial-cell–derived cytokine implicated in the pathogenesis of asthma. This randomized, placebo-controlled clinical trial showed a reduction in the annualized rate of asthma exacerbations among patients with severe, uncontrolled asthma treated with tezepelumab.

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Publisher

Massachusetts Medical Society

Subject

Adolescent

/ Adult

/ Adverse events

/ Age

/ Aged

/ Aged, 80 and over

/ Airway management