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Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis

by Ghezzi, Angelo , Tardieu, Marc , Wolinsky, Jerry S , Bar-Or, Amit , Chitnis, Tanuja , Banwell, Brenda , Merschhemke, Martin , Chen, Yu , Greenberg, Benjamin , Putzki, Norman , Krupp, Lauren , Waubant, Emmanuelle , Arnold, Douglas L , Brück, Wolfgang , Giovannoni, Gavin , Gärtner, Jutta , Rostásy, Kevin , Stites, Tracy

in Adults / Age / Body weight / Clinical trials / Convulsions / FDA approval / Interferon / Leukopenia / Life Sciences / Magnetic resonance imaging / Multiple sclerosis / NMR / Nuclear magnetic resonance / Patients / Pediatrics / Regulatory approval / Tachycardia / Technical communication / β-Interferon

2018

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Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis

2018

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Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis

2018

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Journal Article

Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis

Ghezzi, Angelo,

Tardieu, Marc,

Wolinsky, Jerry S,

Bar-Or, Amit,

Chitnis, Tanuja,

Banwell, Brenda,

Merschhemke, Martin,

Chen, Yu,

Greenberg, Benjamin,

Putzki, Norman,

Krupp, Lauren,

Waubant, Emmanuelle,

Arnold, Douglas L,

Brück, Wolfgang,

Giovannoni, Gavin,

Gärtner, Jutta,

Rostásy, Kevin,

Stites, Tracy

2018

Overview

In 215 patients with a median age of 16 years, fingolimod was superior to interferon beta-1a in reducing relapses of multiple sclerosis and the accumulation of new lesions on MRI over a 2-year period. Seizures occurred in 5.6% of patients in the fingolimod group.

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Publisher

Massachusetts Medical Society

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