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Trial of Tocilizumab in Giant-Cell Arteritis
by
Unizony, Sebastian H
, Tuckwell, Katie
, Cid, Maria C
, Schett, Georg
, Schulze-Koops, Hendrik
, Brouwer, Elisabeth
, Stone, John H
, Klearman, Micki
, Dimonaco, Sophie
, Spiera, Robert
, Collinson, Neil
, Rech, Juergen
, Aringer, Martin
, Salvarani, Carlo
, Blockmans, Daniel
, Dasgupta, Bhaskar
in
Aged
/ Antibodies, Monoclonal, Humanized - adverse effects
/ Antibodies, Monoclonal, Humanized - therapeutic use
/ Arteritis
/ Autoimmune diseases
/ Clinical trials
/ Cytokines
/ Double-Blind Method
/ Drug Administration Schedule
/ Drug dosages
/ Drug therapy
/ Drug Therapy, Combination
/ Female
/ Giant Cell Arteritis - drug therapy
/ Glucocorticoids
/ Glucocorticoids - administration & dosage
/ Glucocorticoids - adverse effects
/ Humans
/ Immunology
/ Immunosuppressive agents
/ Inflammation
/ Injections, Subcutaneous
/ Interleukin 6
/ Ischemia
/ Male
/ Middle Aged
/ Monoclonal antibodies
/ Optic neuropathy
/ Patients
/ Prednisone
/ Prednisone - administration & dosage
/ Prednisone - adverse effects
/ Receptors, Interleukin-6 - antagonists & inhibitors
/ Remission
/ Remission Induction
/ Side effects
/ Vein & artery diseases
/ Veins & arteries
2017
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Trial of Tocilizumab in Giant-Cell Arteritis
by
Unizony, Sebastian H
, Tuckwell, Katie
, Cid, Maria C
, Schett, Georg
, Schulze-Koops, Hendrik
, Brouwer, Elisabeth
, Stone, John H
, Klearman, Micki
, Dimonaco, Sophie
, Spiera, Robert
, Collinson, Neil
, Rech, Juergen
, Aringer, Martin
, Salvarani, Carlo
, Blockmans, Daniel
, Dasgupta, Bhaskar
in
Aged
/ Antibodies, Monoclonal, Humanized - adverse effects
/ Antibodies, Monoclonal, Humanized - therapeutic use
/ Arteritis
/ Autoimmune diseases
/ Clinical trials
/ Cytokines
/ Double-Blind Method
/ Drug Administration Schedule
/ Drug dosages
/ Drug therapy
/ Drug Therapy, Combination
/ Female
/ Giant Cell Arteritis - drug therapy
/ Glucocorticoids
/ Glucocorticoids - administration & dosage
/ Glucocorticoids - adverse effects
/ Humans
/ Immunology
/ Immunosuppressive agents
/ Inflammation
/ Injections, Subcutaneous
/ Interleukin 6
/ Ischemia
/ Male
/ Middle Aged
/ Monoclonal antibodies
/ Optic neuropathy
/ Patients
/ Prednisone
/ Prednisone - administration & dosage
/ Prednisone - adverse effects
/ Receptors, Interleukin-6 - antagonists & inhibitors
/ Remission
/ Remission Induction
/ Side effects
/ Vein & artery diseases
/ Veins & arteries
2017
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Trial of Tocilizumab in Giant-Cell Arteritis
by
Unizony, Sebastian H
, Tuckwell, Katie
, Cid, Maria C
, Schett, Georg
, Schulze-Koops, Hendrik
, Brouwer, Elisabeth
, Stone, John H
, Klearman, Micki
, Dimonaco, Sophie
, Spiera, Robert
, Collinson, Neil
, Rech, Juergen
, Aringer, Martin
, Salvarani, Carlo
, Blockmans, Daniel
, Dasgupta, Bhaskar
in
Aged
/ Antibodies, Monoclonal, Humanized - adverse effects
/ Antibodies, Monoclonal, Humanized - therapeutic use
/ Arteritis
/ Autoimmune diseases
/ Clinical trials
/ Cytokines
/ Double-Blind Method
/ Drug Administration Schedule
/ Drug dosages
/ Drug therapy
/ Drug Therapy, Combination
/ Female
/ Giant Cell Arteritis - drug therapy
/ Glucocorticoids
/ Glucocorticoids - administration & dosage
/ Glucocorticoids - adverse effects
/ Humans
/ Immunology
/ Immunosuppressive agents
/ Inflammation
/ Injections, Subcutaneous
/ Interleukin 6
/ Ischemia
/ Male
/ Middle Aged
/ Monoclonal antibodies
/ Optic neuropathy
/ Patients
/ Prednisone
/ Prednisone - administration & dosage
/ Prednisone - adverse effects
/ Receptors, Interleukin-6 - antagonists & inhibitors
/ Remission
/ Remission Induction
/ Side effects
/ Vein & artery diseases
/ Veins & arteries
2017
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Journal Article
Trial of Tocilizumab in Giant-Cell Arteritis
2017
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Overview
Treatment of giant-cell arteritis with tocilizumab, an interleukin-6 receptor alpha inhibitor, while prednisone was tapered over a 26-week period resulted in higher rates of sustained remission than prednisone tapering plus placebo and reduced the total prednisone dose.
Publisher
Massachusetts Medical Society
Subject
/ Antibodies, Monoclonal, Humanized - adverse effects
/ Antibodies, Monoclonal, Humanized - therapeutic use
/ Drug Administration Schedule
/ Female
/ Giant Cell Arteritis - drug therapy
/ Glucocorticoids - administration & dosage
/ Glucocorticoids - adverse effects
/ Humans
/ Ischemia
/ Male
/ Patients
/ Prednisone - administration & dosage
/ Prednisone - adverse effects
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