Journal Article

Percutaneous Implantation of an Entirely Intracardiac Leadless Pacemaker

Reddy, Vivek Y, Exner, Derek V, Bunch, T. Jared, Plunkitt, Kenneth, Doshi, Rahul, Ip, John, Niazi, Imran, Porterfield, James, Ip, James E, Friedman, Paul A, Tomassoni, Gery F, Dukkipati, Srinivas R, Cantillon, Daniel J, Estes, N.A. Mark, Banker, Rajesh

2015

Overview

In a multicenter study, 526 patients underwent implantation of a new leadless cardiac pacemaker. Among the first 300 patients who were followed for 6 months, the pacemaker met prespecified sensing and pacing requirements in 90%, and serious adverse events were observed in 6.7%. Each year, nearly 1 million persons worldwide receive conventional transvenous cardiac pacemakers with active-fixation leads to treat bradycardia and heart block. 1 , 2 Despite considerable technological advancements since the clinical introduction of these pacemakers six decades ago, pacemaker-related adverse events occur in 1 in 10 patients. 3 – 11 These events are typically related to the transvenous lead, surgical pocket, or pulse generator. 3 , 4 The leads are susceptible to dislodgement, fracture, or insulation failure and can also cause infection, cardiac perforation, venous occlusion, and tricuspid regurgitation. Pulse generators have been associated with infection, pocket hematoma, and skin erosion. 3 – 9 , 12 A recently developed . . .

• Publisher: Massachusetts Medical Society
• Subject: Adult / Aged / Aged, 80 and over / Arrhythmias, Cardiac - mortality / Arrhythmias, Cardiac - therapy / Cardiac arrhythmia / Cardiology / Electrocardiography / Electrocardiography, Ambulatory / Electrodes, Implanted / Equipment Design / Equipment Failure / Female / Follow-Up Studies / Heart / Humans / Intention to Treat Analysis / Male / Middle Aged / Motivation / Pacemaker, Artificial - adverse effects / Pacemakers / Prospective Studies / Safety / Transplants & implants / Ventricle