Journal Article

Normative Data for Insulin-Like Growth Factor 1 in Healthy Children and Adolescents From India

Dutta, Pinaki, Rastogi, Ashu, Gajinder, Dewan, Das, Liza, Ghosh, Jayaditya, Bansal, Dipika, Bhadada, Sanjay Kumar, Korbonits, Márta, Sharma, Sadhna, Marwaha, Raman Kumar, Ravi Teja, Kasagani Venkata, Sachdeva, Naresh, Devi, Nagita, Aggarwal, Arun, Malhotra, Bhanu, Vogel, Mandy, Pal, Rimesh, Monaghan, Phillip J

2024

Overview

Abstract Background Serum insulin-like growth factor 1 (IGF-1) is an important biochemical tool to diagnose and monitor growth hormone (GH)-related disorders. However, ethnicity-specific Indian data, following consensus criteria for the establishment of normative data, are not available. Our objective was to generate chronological age (CA)-, bone age (BA)- and Tanner stage–specific normative data for IGF-1 in healthy Indian children and adolescents. Methods A cross-sectional epidemiological study was conducted in schools and the community, which enrolled apparently healthy children and adolescents with robust exclusion criteria. The outcome measure was serum IGF-1 assessed using an electro-chemiluminescence immunoassay (ECLIA). The 2.5th, 5th, 10th, 25th, 50th (median), 75th, 90th, 95th, and 97.5th centiles for IGF-1 were estimated using generalized additive models. Results We recruited 2226 apparently healthy participants and following exclusion, 1948 (1006 boys, 942 girls) were included in the final analysis. Girls had median IGF-1 peak at CA of 13 years (321.7 ng/mL), BA of 14 years (350.2 ng/mL) and Tanner stage IV (345 ng/mL), while boys had median IGF-1 peak at CA of 15 years (318.9 ng/mL) BA of 15 years (340.6 ng/mL) and Tanner stage III (304.8 ng/mL). Girls had earlier rise, earlier peak, and higher IGF-1 values. The reference interval (2.5th to 97.5th percentile) was broader during peripubertal ages, indicating a higher physiological variability. Conclusion This study provides ethnicity-specific normative data on serum IGF-1 and will improve the diagnostic utility of IGF-1 in the evaluation and management of growth disorders in Indian children and adolescents.

• Publisher: Oxford University Press
• Subject: Adolescent / Adolescents / Age Determination by Skeleton / Biomarkers - blood / Chemiluminescence / Child / Children / Children & youth / Cross-Sectional Studies / Epidemiology / Ethnicity / Female / Growth hormones / Health aspects / Healthy Volunteers / Humans / India / Insulin / Insulin-like growth factor 1 / Insulin-like growth factor I / Insulin-Like Growth Factor I - analysis / Insulin-Like Growth Factor I - metabolism / Insulin-like growth factors / Insulin-Like Peptides / Male / Minority & ethnic groups / Reference Values / Teenagers / Youth