Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Immunohistochemical Expression of Preferentially Expressed Antigen in Melanoma (PRAME) in the Uninvolved Background Testis, Germ Cell Neoplasia In Situ, and Germ Cell Tumors of the Testis

by Grillini, Marco , Ambrosi, Francesca , Giunchi, Francesca , Ricci, Costantino , Colecchia, Maurizio , Franceschini, Tania , Massari, Francesco , Mollica, Veronica , Fiorentino, Michelangelo

in Antigens / Antigens, Neoplasm / Differential diagnosis / Germ cell tumors / Germ cells / Humans / Male / Melanoma / Melanoma - pathology / Neoplasms, Germ Cell and Embryonal - pathology / Pluripotency / Retrospective Studies / Seminoma / Seminoma - metabolism / Seminoma - pathology / Testes / Testicular Neoplasms - pathology / Testis - pathology / Tumors

2022

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Immunohistochemical Expression of Preferentially Expressed Antigen in Melanoma (PRAME) in the Uninvolved Background Testis, Germ Cell Neoplasia In Situ, and Germ Cell Tumors of the Testis

by Grillini, Marco , Ambrosi, Francesca , Giunchi, Francesca , Ricci, Costantino , Colecchia, Maurizio , Franceschini, Tania , Massari, Francesco , Mollica, Veronica , Fiorentino, Michelangelo

2022

Confirm

Do you wish to request the book?

Immunohistochemical Expression of Preferentially Expressed Antigen in Melanoma (PRAME) in the Uninvolved Background Testis, Germ Cell Neoplasia In Situ, and Germ Cell Tumors of the Testis

by Grillini, Marco , Ambrosi, Francesca , Giunchi, Francesca , Ricci, Costantino , Colecchia, Maurizio , Franceschini, Tania , Massari, Francesco , Mollica, Veronica , Fiorentino, Michelangelo

2022

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Immunohistochemical Expression of Preferentially Expressed Antigen in Melanoma (PRAME) in the Uninvolved Background Testis, Germ Cell Neoplasia In Situ, and Germ Cell Tumors of the Testis

Grillini, Marco,

Ambrosi, Francesca,

Giunchi, Francesca,

Ricci, Costantino,

Colecchia, Maurizio,

Franceschini, Tania,

Massari, Francesco,

Mollica, Veronica,

Fiorentino, Michelangelo

2022

Overview

Abstract Objectives Preferentially expressed antigen in melanoma (PRAME) has a key role in regulating pluripotency of primordial germ cells and in the development of germ cell tumors of the testis (GCTT). However, its immunohistochemical expression in normal testes and its neoplastic counterpart remain largely unknown. Methods We retrospectively investigated the expression of PRAME in 26 cases of GCTT, 21 cases of germ cell neoplasia in situ (GCNIS), and 17 cases of uninvolved background testes. Results We found that PRAME was expressed more strongly by seminomatous rather than nonseminomatous GCTT (P = .000) and by pure seminoma rather than the seminoma component of seminomatous/nonseminomatous GCTT (P = .025). In addition, GCNIS and uninvolved background testes displayed high levels of PRAME expression. Conclusions PRAME is an additional marker for the differential diagnosis of GCTT and could play a key role in the transition from seminomatous to nonseminomatous GCTT.

Share this book

Add to My Shelf

Publisher

Oxford University Press

Subject

Antigens

/ Antigens, Neoplasm

/ Differential diagnosis

/ Germ cell tumors

/ Germ cells

/ Humans

/ Male