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Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults

by Kapoor, Archana , Ghaswalla, Parinaz , Du, Jiejun , Doreski, Pablo A. , Mehta, Shraddha , Perez-Marc, Gonzalo , Panozzo, Catherine A. , Zaman, Khalequ , Monroy, Jorge , Dhar, Rakesh , Miller, Jacqueline M. , Goswami, Jaya , Walsh, Edward E. , Simorellis, Alana K. , Stoszek, Sonia K. , Falsey, Ann R. , Wilson, Eleanor , Kuter, Barbara J. , Das, Rituparna , Reuter, Caroline , Slobod, Karen , Pérez-Breva, Lina , Rämet, Mika , Wilson, Lauren , Shaw, Christine A. , Lan, Lan , Baqui, Abdullah H. , Duncan, Christopher J.A. , Mithani, Runa , Huang, Wenmei , Ujiie, Mugen , Schödel, Florian , Chen, Grace L.

in Aged / Aging / Aging General / Antibodies, Viral / Chronic obstructive pulmonary disease / Clinical Medicine / Clinical Medicine General / Clinical trials / Confidence intervals / Critical Care / Critical Care General / Double-Blind Method / Geriatrics / Glycoproteins / Humans / Infections / Infectious Disease / Infectious Disease General / Middle Aged / Morbidity / mRNA / mRNA Vaccines - adverse effects / mRNA Vaccines - therapeutic use / Older people / Outpatient-Based Clinical Medicine / Placebos / Product development / Pulmonary / Respiratory diseases / Respiratory syncytial virus / Respiratory Syncytial Virus Infections - epidemiology / Respiratory Syncytial Virus Infections - prevention & control / Respiratory Syncytial Virus Vaccines - adverse effects / Respiratory Syncytial Virus Vaccines - therapeutic use / Respiratory Syncytial Virus, Human - genetics / Respiratory tract diseases / Respiratory Tract Diseases - diagnosis / Respiratory Tract Diseases - epidemiology / Respiratory Tract Diseases - prevention & control / Safety / Side effects / Statistical analysis / Success / Treatment Outcome / Vaccine efficacy / Vaccines / Viral Infections

2023

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Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults

2023

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Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults

2023

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Journal Article

Efficacy and Safety of an mRNA-Based RSV PreF Vaccine in Older Adults

Kapoor, Archana,

Ghaswalla, Parinaz,

Du, Jiejun,

Doreski, Pablo A.,

Mehta, Shraddha,

Perez-Marc, Gonzalo,

Panozzo, Catherine A.,

Zaman, Khalequ,

Monroy, Jorge,

Dhar, Rakesh,

Miller, Jacqueline M.,

Goswami, Jaya,

Walsh, Edward E.,

Simorellis, Alana K.,

Stoszek, Sonia K.,

Falsey, Ann R.,

Wilson, Eleanor,

Kuter, Barbara J.,

Das, Rituparna,

Reuter, Caroline,

Slobod, Karen,

Pérez-Breva, Lina,

Rämet, Mika,

Wilson, Lauren,

Shaw, Christine A.,

Lan, Lan,

Baqui, Abdullah H.,

Duncan, Christopher J.A.,

Mithani, Runa,

Huang, Wenmei,

Ujiie, Mugen,

Schödel, Florian,

Chen, Grace L.

2023

Overview

In a placebo-controlled, phase 2–3 trial, one dose of mRNA-1345 led to a lower incidence of RSV disease among adults 60 years of age or older. Solicited local and systemic adverse reactions occurred more often with the vaccine.

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Publisher

Massachusetts Medical Society

Subject

Aged

/ Aging

/ Aging General

/ Antibodies, Viral

/ Chronic obstructive pulmonary disease

/ Clinical Medicine

/ Clinical Medicine General