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Development of novel aptamers for low-density lipoprotein particle quantification
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Development of novel aptamers for low-density lipoprotein particle quantification
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Journal Article
Development of novel aptamers for low-density lipoprotein particle quantification
2018
Overview
Cardiovascular disease (CVD) remains the leading cause of death worldwide. Low-density lipoprotein cholesterol (LDL-C) is commonly used for CVD risk assessment; however, recent research has shown LDL particle (LDL-P) number to be a more sensitive indicator of CVD risk than both LDL-C and non-high-density lipoprotein cholesterol (HDL-C). Described herein are five single stranded DNA aptamers with dissociation constants in the low picomolar range specific to LDL-P and its subfractions. Furthermore, a set of antisense sequences have been developed and characterized that are capable of binding to the best aptamers and undergoing displacement by LDL-P for use in a simple, affordable diagnostic assay.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Aptamers
/ Density
/ DNA
/ Ligands
/ Lipids
/ Medicine and Health Sciences
/ Methods
/ NMR
/ Proteins
