Journal Article

Physiology Is a Stronger Predictor of Survival than Pathology in Fibrotic Interstitial Pneumonia

Travis, William D, Jegal, Yangjin, Do Lee, Sang, Colby, Thomas V, Shim, Tae Sun, Kim, Dong Soon, Koh, Younsuck, Kitaichi, Masanori, Lim, Chae-Man, Kim, Woo Sung, Lee, Jin Seong, Kim, Won Dong

2005

Overview

The histopathologic pattern provides the most important prognostic marker for idiopathic interstitial pneumonia; however, studies have suggested that short-term changes in lung function may be more important. We investigated the prognostic factors for fibrotic interstitial pneumonia. The clinical features and follow-up course of 179 patients (131 with idiopathic pulmonary fibrosis and 48 with nonspecific interstitial pneumonia; 41 fibrotic types and 7 cellular) were analyzed retrospectively. The lung function indices improved or stabilized in most patients with fibrotic nonspecific interstitial pneumonia in contrast to the deterioration or stable condition of most patients with idiopathic pulmonary fibrosis. The 5-year survival of patients with fibrotic nonspecific interstitial pneumonia (76.2%) was better than for those with idiopathic pulmonary fibrosis (43.8%) (p = 0.007). Multivariate analysis at the time of presentation revealed that pathologic pattern, age, and diffusion capacity had important prognostic implications. However, after 6 months of follow-up, changes in FVC, initial diffusion capacity, and sex were the only independent prognostic factors, with no additional prognostic information conferred by the histologic diagnosis. Our data confirmed the importance of physiological parameters including short-term change in FVC. However, at the time of diagnosis, histopathology was important for the prediction of prognosis and future change in lung function.

• Publisher: Am Thoracic Soc,American Lung Association,Oxford University Press
• Subject: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy / Biological and medical sciences / Biopsy / Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care / Emergency and intensive respiratory care / Female / Follow-Up Studies / Humans / Intensive care medicine / Lung - pathology / Lung Diseases, Interstitial - mortality / Lung Diseases, Interstitial - pathology / Lung Diseases, Interstitial - physiopathology / Male / Medical prognosis / Medical records / Medical sciences / Middle Aged / Multivariate Analysis / Ostomy / Physiology / Pneumonia / Prognosis / Pulmonary fibrosis / Pulmonary Fibrosis - mortality / Pulmonary Fibrosis - pathology / Pulmonary Fibrosis - physiopathology / Regression analysis / Respiratory Function Tests / Survival Rate / Time Factors / Tomography, X-Ray Computed - methods