Journal Article

Antibacterial activity of trimetal (CuZnFe) oxide nanoparticles

Niazy, Abdurahman, Alghamdi, Hamdan, Wahab, Rizwan, Alswieleh, Abdullah, El-Toni, Ahmed, Alzahrani, Khalid

2018

Overview

The increasing resistance of pathogenic bacteria to antibiotics is a challenging worldwide health problem that has led to the search for new and more efficient antibacterial agents. Nanotechnology has proven to be an effective tool for the fight against bacteria. In this paper, we present the synthesis and traits of trimetal (CuZnFe) oxide nanoparticles (NPs) using X-ray diffraction, high-resolution transmission electron microscopy, and energy dispersive x-ray spectroscopy. We evaluated the antibacterial activity of these NPs against gram-negative and gram-positive and then compared it to that of their pure single-metal oxide components CuO and ZnO. Our study showed that the antibacterial activity of the trimetal oxide NPs was greater against . than against . . Overall, the antimicrobial effect of trimetal NPs is between those of pure ZnO and CuO nanoparticles, which may mean that their cytotoxicity is also between that of pure ZnO and CuO NPs, making them potential antibiotics. However, the cytotoxicity of trimetal NPs to mammalian cells needs to be verified. The combination of three metal oxide NPs (ZnO, CuO, and Fe O ) in one multimetal (CuZnFe) oxide NPs will enhance the therapeutic strategy against a wide range of microbial infections. Bacteria are unlikely to develop resistance against this new NP because bacteria must go through a series of mutations to become resistant to the trimetal oxide NP. Therefore, this NP can combat existing and emerging bacterial infections.

• Publisher: Dove Medical Press Limited,Taylor & Francis Ltd,Dove Medical Press
• Subject: Anti-Bacterial Agents - chemistry / Anti-Bacterial Agents - pharmacology / Antibacterial agents / Antibiotics / Apoptosis / Bacteria / Bacterial infections / Biofilms / Cancer / Cells (Biology) / Comparative analysis / Copper / Copper - chemistry / Copper - pharmacology / Copper oxides / Drug Evaluation, Preclinical - methods / Drug resistance / Drug Stability / E coli / Electron microscopy / Enterococcus faecalis / Enterococcus faecalis - drug effects / Escherichia coli / Escherichia coli - drug effects / Ferric Compounds - chemistry / Ferric Compounds - pharmacology / Gram-negative bacteria / Gram-positive bacteria / Health / Investigations / Metal Nanoparticles - chemistry / Metal oxides / Metals (Materials) / Methicillin / Microbial drug resistance / Microscopy / Microscopy, Electron, Transmission / Nanoparticles / Nanotechnology / Nanotechnology - methods / Original Research / Oxidative stress / Quantum dots / Spectroscopy / Staphylococcus infections / trimetal nanoparticles / X-Ray Diffraction / X-ray spectroscopy / Zinc Oxide - chemistry / Zinc Oxide - pharmacology / Zinc oxides