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Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics
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Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics
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Journal Article
Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics
2018
Overview
Salvia miltiorrhiza
Burge (Danshen) is an eminent medicinal herb that possesses broad cardiovascular and cerebrovascular protective actions and has been used in Asian countries for many centuries. Accumulating evidence suggests that Danshen and its components prevent vascular diseases, in particular, atherosclerosis and cardiac diseases, including myocardial infarction, myocardial ischemia/reperfusion injury, arrhythmia, cardiac hypertrophy and cardiac fibrosis. The published literature indicates that lipophilic constituents (tanshinone I, tanshinone IIa, tanshinone IIb, cryptotanshinone, dihydrotanshinone,
etc
) as well as hydrophilic constituents (danshensu, salvianolic acid A and B, protocatechuic aldehyde,
etc
) contribute to the cardiovascular protective actions of Danshen, suggesting a potential synergism among these constituents. Herein, we provide a systematic up-to-date review on the cardiovascular actions and therapeutic potential of major pharmacologically active constituents of Danshen. These bioactive compounds will serve as excellent drug candidates in small-molecule cardiovascular drug discovery. This article also provides a scientific rationale for understanding the traditional use of Danshen in cardiovascular therapeutics.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Biomedical and Life Sciences
/ Cardiotonic Agents - therapeutic use
/ Cardiovascular Diseases - drug therapy
/ Cardiovascular Diseases - physiopathology
/ Drugs, Chinese Herbal - therapeutic use
/ Endothelial Cells - drug effects
/ Fibrinolytic Agents - therapeutic use
/ Fibrosis
/ Humans
/ Ischemia
/ Muscle, Smooth, Vascular - drug effects
/ Myocytes, Smooth Muscle - drug effects
/ Review
/ Traditional Chinese medicine
/ Vaccine
