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Effect of Lactobacillus brevis CD2 containing lozenges and plaque pH and cariogenic bacteria in diabetic children: a randomised clinical trial
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Effect of Lactobacillus brevis CD2 containing lozenges and plaque pH and cariogenic bacteria in diabetic children: a randomised clinical trial
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Effect of Lactobacillus brevis CD2 containing lozenges and plaque pH and cariogenic bacteria in diabetic children: a randomised clinical trial
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Journal Article
Effect of Lactobacillus brevis CD2 containing lozenges and plaque pH and cariogenic bacteria in diabetic children: a randomised clinical trial
2021
Overview
Objective
The short-term effect (60 days) of
Lactobacillus brevis
CD2 lozenges vs placebo on variables related to caries and gingivitis in type 1 diabetic children was evaluated.
Material and methods
Eight diabetics (4–14 years old) were assigned to two groups (
n
= 34 subjects each), probiotic lozenges and placebo. Stimulated saliva for microbiological analysis and plaque pH were assessed at baseline (
t
0
), 30 days (
t
1
), 60 days (
t
2
) and in the follow-up period (90 days from baseline,
t
3
). Gingival status was assessed at
t
0
,
t
2
and
t
3
. Two-way ANOVA assessed differences between groups.
Results
In the probiotic group,
Streptococcus mutans
bacterial density mean scores dropped from 3.11 ± 1.13 at baseline to 1.82 ± 0.72 (
t
2
) and to 2.06 ± 0.56 (
t
3
), while in the placebo group, the scores were 3.09 ± 0.8 (
t
0
), 2.82 ± 0.47 (
t
2
) and 3.11 ± 0.43 (
t
3
) (
p
< 0.01). Lowest and maximum pH fall increased in the probiotic group, from 5.37 ± 0.41 at baseline to 5.49 ± 0.24 at
t
3
(
p
< 0.01) and from 1.20 ± 0.46 to 0.98 ± 0.29 (
p
= 0.02). Bleeding score decreased significantly in both groups, showing a statistically significant lower bleeding score at
t
2
in the probiotic group (25.6%, 95% CI 21.5–32.7 vs 29.5%, 95% CI 25.2–34.9,
p
= 0.02).
Conclusions
Lactobacillus brevis
CD2 has shown to improve caries-related risk factors and gingival health in diabetic children.
Clinical relevance
Lactobacillus brevis
CD2 might contribute to improved oral health in type 1 diabetic children.
