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Genetic variants in arachidonic acid pathway genes associated with NSAID-exacerbated respiratory disease
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Genetic variants in arachidonic acid pathway genes associated with NSAID-exacerbated respiratory disease
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Journal Article
Genetic variants in arachidonic acid pathway genes associated with NSAID-exacerbated respiratory disease
2015
Overview
NSAIDs are the most frequent cause of hypersensitivity drug reactions. We have examined the association between NSAID-exacerbated respiratory disease (NERD) and genetic variants in arachidonic acid metabolism genes.
We included 250 NERD patients, 260 NSAID-tolerant asthmatic (NTA) subjects and 315 healthy controls.
Significant associations with NERD were identified for:
rs3892408 C/C homozygous genotype (NERD vs NTA; p = 0.0001, pc = 0.0011; NERD vs controls; p = 0.0001, pc = 0.0011),
rs5789 A/A homozygous genotype (NERD vs NTA; p = 0.0001, pc = 0.0011; NERD vs controls; p = 0.0001, pc = 0.0011),
rs10306135 A/A homozygous genotype (NERD vs NTA; p = 0.0009, pc = 0.0091; NERD vs controls; p = 0.0064, pc = 0.045). Differences in
copy number variations were also found (NERD vs NTA; p = 0.010; NERD vs controls; p = 0.0001).
These results improve our understanding of the underlying mechanisms of NERD and may help develop a predictive test for this pathology.
Original submitted 3 November 2014; Revision submitted 2 April 2015
Publisher
Future Medicine Ltd
Subject
/ Aged
/ Anti-Inflammatory Agents, Non-Steroidal - adverse effects
/ Anti-Inflammatory Agents, Non-Steroidal - toxicity
/ Arachidonate 15-Lipoxygenase - genetics
/ Arachidonic Acid - metabolism
/ Asthma, Aspirin-Induced - genetics
/ Asthma, Aspirin-Induced - pathology
/ Drug Hypersensitivity - genetics
/ Female
/ Humans
/ hypersensitivity drug reactions
/ Identification and classification
/ Male
/ Metabolic Networks and Pathways
/ NSAID-exacerbated respiratory disease
/ NSAIDs
