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Gut microbiota–generated metabolites in animal health and disease
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Journal Article
Gut microbiota–generated metabolites in animal health and disease
2014
Overview
Understanding the mechanisms by which gut metabolites impact host physiology should help understand a variety of disease associated with gut-microbiota dysbiosis. A review of this microbial impact in both invertebrate and vertebrate highlights roles in energy harvest, pathogen resistance and the development of allergic and neurological disorders.
Gut microbiota is found in virtually any metazoan, from invertebrates to vertebrates. It has long been believed that gut microbiota, more specifically, the activity of the microbiome and its metabolic products, directly influence a variety of aspects in metazoan physiology. However, the exact molecular relationship among microbe-derived gut metabolites, host signaling pathways, and host physiology remains to be elucidated. Here we review recent discoveries regarding the molecular links between gut metabolites and host physiology in different invertebrate and vertebrate animal models. We describe the different roles of gut microbiome activity and their metabolites in regulating distinct host physiology and the molecular mechanisms by which gut metabolites cause physiological homeostasis via regulating specific host signaling pathways. Future studies in this direction using different animal models will provide the key concepts to understanding the evolutionarily conserved chemical dialogues between gut microbiota and metazoan cells and also human diseases associated with gut microbiota and metabolites.
Publisher
Nature Publishing Group US,Nature Publishing Group
