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Therapeutic Potentials of the Seaweed-Derived Compounds for Alzheimer’s Disease
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Therapeutic Potentials of the Seaweed-Derived Compounds for Alzheimer’s Disease
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Journal Article
Therapeutic Potentials of the Seaweed-Derived Compounds for Alzheimer’s Disease
2025
Overview
Cognitive decline associated with healthy ageing and pathological conditions is driven by multifactorial processes, including oxidative stress, mitochondrial dysfunction and chronic neuroinflammation. Alzheimer’s Disease (AD), a progressive neurodegenerative disorder affecting cognition and behaviour, is the leading cause of dementia worldwide. Current pharmacological interventions provide modest and transient benefits, targeting limited molecular pathways with safety and cost concerns, underscoring the need for safe, accessible and multi-targeted strategies. This review explores new avenues of therapy with a focus on bioactive compounds derived from brown, red and green seaweeds and their potential to modulate key mechanisms underlying AD. Preclinical and emerging clinical studies demonstrate that phlorotannins, fucoidans, fucoxanthin, lutein, zeaxanthin, ulvan, and astaxanthin exert antioxidant, anti-inflammatory, cholinergic-modulating and neuroprotective effects. Supplementation with seaweed-derived bioactive compounds has been shown to exert molecular and cellular effects that lead to reduced amyloid burden, preservation of synaptic integrity, and enhanced cognitive performance. Collectively, seaweed-derived compounds represent promising candidates for multi-target therapeutic strategies in cognitive decline prevention in the context of AD and healthy brain ageing.
Publisher
MDPI AG
Subject
/ Aging
/ Alzheimer Disease - drug therapy
/ Alzheimer Disease - metabolism
/ Animals
/ Anti-Inflammatory Agents - chemistry
/ Anti-Inflammatory Agents - pharmacology
/ Anti-Inflammatory Agents - therapeutic use
/ Antioxidants - therapeutic use
/ B cells
/ Dementia
/ Diseases
/ Humans
/ Kinases
/ Memory
/ Neuroprotective Agents - chemistry
/ Neuroprotective Agents - pharmacology
/ Neuroprotective Agents - therapeutic use
/ Oxidative Stress - drug effects
/ Peptides
/ Proteins
/ seaweeds
