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A Trial of Itraconazole or Amphotericin B for HIV-Associated Talaromycosis
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A Trial of Itraconazole or Amphotericin B for HIV-Associated Talaromycosis
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Journal Article
A Trial of Itraconazole or Amphotericin B for HIV-Associated Talaromycosis
2017
Overview
Talaromyces marneffei
is a dimorphic fungus that causes substantial disease in Asia, especially among persons infected with the human immunodeficiency virus. In this randomized, controlled trial, initial therapy with amphotericin B was found to be superior to itraconazole.
The dimorphic fungus
Talaromyces
(previously
Penicillium
)
marneffei
causes a life-threatening mycosis in immunocompromised persons living in or traveling to Southeast Asia, China, and India.
1
Talaromycosis (previously penicilliosis) is a major cause of human immunodeficiency virus (HIV)–related death; its prevalence is surpassed only by the prevalence of tuberculosis and cryptococcosis,
2
and it leads to 4 to 15% of HIV-related hospital admissions in regions in which the disease is endemic.
3
–
7
Talaromycosis is increasingly diagnosed among patients who are not infected with HIV but who have other immunodeficiency conditions
8
and is reported to be the second most common cause of all . . .
Publisher
Massachusetts Medical Society
Subject
/ Adult
/ AIDS-Related Opportunistic Infections - drug therapy
/ AIDS-Related Opportunistic Infections - mortality
/ Amphotericin B - adverse effects
/ Amphotericin B - therapeutic use
/ Anemia
/ Antifungal Agents - adverse effects
/ Antifungal Agents - therapeutic use
/ Deoxycholic Acid - adverse effects
/ Deoxycholic Acid - therapeutic use
/ Female
/ HIV
/ Human immunodeficiency virus
/ Humans
/ Induction Chemotherapy - adverse effects
/ Infusions, Intravenous - adverse effects
/ Itraconazole - adverse effects
/ Itraconazole - therapeutic use
/ Kidneys
/ Male
