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Immunoexpression of stem cell markers SOX-2, NANOG AND OCT4 in ameloblastoma

by Alves Mesquita, Ricardo , Viana Pinheiro, João de Jesus , Chemelo, Giordanna Pereira , da Costa da Silva, Artur Luiz , Martins Balbinot, Karolyny , Cruz Ramos, Aline Maria Pereira , Ramos, Rommel Thiago Jucá , da Silva Kataoka, Maria Sueli , Alves Junior, Sergio de Melo , de Menezes, Sílvio Augusto Fernandes , Almeida Loureiro, Felippe José

in Ameloblastoma / Ameloblastoma - genetics / Ameloblastoma - metabolism / Biochemistry / Bioinformatics / Biomarkers - metabolism / Biomarkers, Tumor - genetics / Biomarkers, Tumor - metabolism / Cell Biology / Cell Proliferation / Genomics / Humans / Immunohistochemistry / Nanog Homeobox Protein - genetics / Neoplastic Stem Cells - metabolism / Octamer Transcription Factor-3 - genetics / Octamer Transcription Factor-3 - metabolism / Octamer transcription factors / Proteins / SOX transcription factors / SOXB1 Transcription Factors - genetics / SOXB1 Transcription Factors - metabolism / Stem cell research / Stem cells / Stem Cells - metabolism / Transcriptomic

2023

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Immunoexpression of stem cell markers SOX-2, NANOG AND OCT4 in ameloblastoma

2023

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Immunoexpression of stem cell markers SOX-2, NANOG AND OCT4 in ameloblastoma

2023

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Journal Article

Immunoexpression of stem cell markers SOX-2, NANOG AND OCT4 in ameloblastoma

Alves Mesquita, Ricardo,

Viana Pinheiro, João de Jesus,

Chemelo, Giordanna Pereira,

da Costa da Silva, Artur Luiz,

Martins Balbinot, Karolyny,

Cruz Ramos, Aline Maria Pereira,

Ramos, Rommel Thiago Jucá,

da Silva Kataoka, Maria Sueli,

Alves Junior, Sergio de Melo,

de Menezes, Sílvio Augusto Fernandes,

Almeida Loureiro, Felippe José

2023

Overview

Ameloblastoma (AME) is characterized by a locally invasive growth pattern. In an attempt to justify the aggressiveness of neoplasms, the investigation of the role of stem cells has gained prominence. The SOX-2, NANOG and OCT4 proteins are important stem cell biomarkers. To verify the expression of these proteins in tissue samples of AME, dentigerous cyst (DC) and dental follicle (DF), immunohistochemistry was performed and indirect immunofluorescence were performed on the human AME (AME-hTERT) cell line. Revealed expression of SOX-2, NANOG and OCT4 in the tissue samples and AME-hTERT lineage. Greater immunostaining of the studied proteins was observed in AME compared to DC and DF ( < 0.001). The presence of biomarkers indicates a probable role of stem cells in the genesis and progression of AME.

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Publisher

PeerJ. Ltd,PeerJ Inc

Subject

Ameloblastoma

/ Ameloblastoma - genetics

/ Ameloblastoma - metabolism

/ Biochemistry

/ Bioinformatics

/ Biomarkers - metabolism

/ Biomarkers, Tumor - genetics