Asset Details
Do you wish to reserve the book?
Oxidative stress biomarkers in mitochondrial myopathies, basally and after cysteine donor supplementation
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Oxidative stress biomarkers in mitochondrial myopathies, basally and after cysteine donor supplementation
Do you wish to request the book?
Oxidative stress biomarkers in mitochondrial myopathies, basally and after cysteine donor supplementation
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Oxidative stress biomarkers in mitochondrial myopathies, basally and after cysteine donor supplementation
2010
Overview
Mitochondrial diseases are due to impairment of the mitochondrial respiratory chain. A plausible pathogenic mechanism leading to cellular dysfunction and phenotypic expression is oxidative stress, but there are surprisingly few clinical studies on this subject. Glutathione (GSH) deficiency has been reported in mitochondrial diseases, and the biosynthesis of glutathione depends on cysteine availability. We have examined oxidative stress biomarkers [advanced oxidation protein products (AOPP) and ferric reducing antioxidant power (FRAP)] in blood samples from 27 patients and 42 controls. AOPP levels were greater in patients than in controls (
P
value <0.00001). Therefore, we performed a double-blind cross-over study to evaluate if 30-day supplementation with a whey-based cysteine donor could modify these markers, reduce lactate concentration during aerobic exercise, or enhance muscular strength and quality of life. Treatment did not modify lactate concentration, clinical scale (MRC) or quality of life (SF-36), but significantly reduced oxidative stress levels. Our findings reinforce the notions that in mitochondrial diseases oxidative stress is important and can be reduced by administration of a cysteine donor. Oxidative stress biomarkers may be useful to detect redox imbalance in mitochondrial diseases and to provide non-invasive tools to monitor disease status.
Publisher
Springer-Verlag,Springer,Springer Nature B.V
Subject
/ Antioxidants - administration & dosage
/ Antioxidants - therapeutic use
/ Biological and medical sciences
/ Cysteine - administration & dosage
/ Diseases of striated muscles. Neuromuscular diseases
/ Exercise
/ Female
/ Humans
/ Male
/ Medicine
/ Mitochondrial Myopathies - blood
/ Mitochondrial Myopathies - drug therapy
/ Plasma
/ Proteins
