Journal Article

Comparison of carbamazepine and oxcarbazepine effects on aminothiol levels

Crespel, Arielle, Cristol, Jean-Paul, Hillaire-Buys, Dominique, Charasson, Virginie, Breton, Hélène, Peyriere, Hélène, Gelisse, Philippe, Badiou, Stéphanie

2008

Overview

Objective The aim of our study was to investigate the effects of carbamazepine (CBZ) and oxcarbazepine (OXCBZ) on aminothiol levels, including homocysteine (Hcy), cysteine, and cysteinylglycine, in chronically treated patients. Methods Epileptic patients receiving CBZ or OXCBZ were recruited as part of routine clinical practice. Demographic data and concomitant medications were recorded from the patient medical file. Results Sixty patients were included in the study; 30 patients were treated with CBZ and 30 with OXCBZ. Median Hcy level was significantly higher in CBZ-treated patients (20.6 μmol/l) than in OXCBZ-treated patients (14.0 μmol/l, p  < 0.0001). No correlation was evidenced between antiepileptic drugs or metabolite levels and Hcy levels for each group. Conclusions Less change observed with OXCBZ compared with CBZ on aminothiol levels could constitute an advantage for OXCBZ treatment in patients with other factors influencing Hcy levels and/or at high risk for cardiovascular diseases.

• Publisher: Springer-Verlag,Springer,Springer Nature B.V,Springer Verlag
• Subject: Adolescent / Adult / Anticonvulsants - pharmacology / Biochemistry / Biological and medical sciences / Biomedical and Life Sciences / Biomedicine / Carbamazepine - analogs & derivatives / Carbamazepine - pharmacology / Cardiovascular Diseases - complications / Cysteine - blood / Dipeptides - blood / Drug therapy / Epilepsy / Epilepsy - drug therapy / Female / Homocysteine - blood / Humans / Life Sciences / Male / Medical sciences / Middle Aged / Pharmacology / Pharmacology. Drug treatments / Pharmacology/Toxicology / Risk Factors / Short Communication