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Once-Weekly Semaglutide in Adults with Overweight or Obesity

by Batterham, Rachel L , Rosenstock, Julio , Wharton, Sean , Davies, Melanie , Wilding, John P.H , McGowan, Barbara M , Zeuthen, Niels , Van Gaal, Luc F , Kushner, Robert F , Tran, Marie T.D , Yokote, Koutaro , Wadden, Thomas A , Lingvay, Ildiko , Calanna, Salvatore

in Adult / Adverse events / Anti-Obesity Agents - administration & dosage / Anti-Obesity Agents - adverse effects / Body composition / Body Composition - drug effects / Body Mass Index / Body weight / Body weight loss / Cardiovascular disease / Cholelithiasis - chemically induced / Clinical trials / Coronaviruses / COVID-19 / Diabetes / Diabetes mellitus / Diarrhea / Diarrhea - chemically induced / Diet / Dosage / Double-Blind Method / Drug therapy / Female / Gastrointestinal surgery / Glucagon-Like Peptide 1 - agonists / Glucagon-Like Peptides - administration & dosage / Glucagon-Like Peptides - adverse effects / Health aspects / Healthy Lifestyle / Humans / Hypertension / Injections, Subcutaneous / Intervention / Lifestyles / Lipids - blood / Male / Medical examination / Middle Aged / Nausea / Nausea - chemically induced / Obesity / Obesity - complications / Obesity - drug therapy / Overweight / Overweight persons / Pancreatitis / Patient outcomes / Physiological aspects / Placebos / Prediabetic State - complications / Public health / Risk factors / Weight control / Weight Loss - drug effects

2021

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Once-Weekly Semaglutide in Adults with Overweight or Obesity

2021

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2021

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Journal Article

Once-Weekly Semaglutide in Adults with Overweight or Obesity

Batterham, Rachel L,

Rosenstock, Julio,

Wharton, Sean,

Davies, Melanie,

Wilding, John P.H,

McGowan, Barbara M,

Zeuthen, Niels,

Van Gaal, Luc F,

Kushner, Robert F,

Tran, Marie T.D,

Yokote, Koutaro,

Wadden, Thomas A,

Lingvay, Ildiko,

Calanna, Salvatore

2021

Overview

This double-blind study randomly assigned adults with obesity (or overweight and with one or more weight-related coexisting conditions) without diabetes to 68 weeks of once-weekly subcutaneous semaglutide (2.4 mg) or placebo, plus lifestyle intervention. Semaglutide therapy was associated with sustained, clinically relevant weight reduction.

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Publisher

Massachusetts Medical Society

Subject

Adult

/ Adverse events

/ Anti-Obesity Agents - administration & dosage

/ Anti-Obesity Agents - adverse effects

/ Body composition

/ Body Composition - drug effects

/ Body Mass Index