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Disrupted Splenic Architecture, but Normal Lymph Node Development in Mice Expressing a Soluble lymphotoxin-β Receptor-IgG1 Fusion Protein
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Disrupted Splenic Architecture, but Normal Lymph Node Development in Mice Expressing a Soluble lymphotoxin-β Receptor-IgG1 Fusion Protein
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Disrupted Splenic Architecture, but Normal Lymph Node Development in Mice Expressing a Soluble lymphotoxin-β Receptor-IgG1 Fusion Protein
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Journal Article
Disrupted Splenic Architecture, but Normal Lymph Node Development in Mice Expressing a Soluble lymphotoxin-β Receptor-IgG1 Fusion Protein
1996
Overview
Early in ontogeny, the secondary lymphoid organs become populated with numerous cells of mesodermal origin which forms both the lymphoid and stromal elements. The critical receptor/ligand interactions necessary for lymphoid organogenesis to occur are for the most part unknown. Although lymphotoxin-α (LTα ) has been shown to be required for normal lymph node, Peyer's patch, and splenic development, it is unclear if soluble LTα 3, and/or cell-bound lymphotoxin-α β (LTα β ) mediate these developmental events. Here we report that blocking LTα β /lymphotoxin-β receptor (LTβ R) interaction in vivo by generating mice which express a soluble LTβ R-Fc fusion protein driven by the human cytomegalovirus promoter results in an array of anatomic abnormalities affecting both the spleen and Peyer's patches, but not the lymph nodes. These results demonstrate that surface LTα β ligand plays a critical role in normal lymphoid organ development.
Publisher
National Academy of Sciences of the United States of America,National Acad Sciences,The National Academy of Sciences of the USA
Subject
/ Animals
/ Humans
/ Immunoglobulin G - biosynthesis
/ Ligands
/ Lymph Nodes - growth & development
/ Lymphotoxin-alpha - metabolism
/ Membrane Proteins - metabolism
/ Mice
/ Peyer's Patches - growth & development
/ Peyer's Patches - immunology
/ Receptors, Tumor Necrosis Factor - biosynthesis
/ Receptors, Tumor Necrosis Factor - genetics
/ Recombinant Fusion Proteins - biosynthesis
/ Spleen
