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Curcumin protects against ischemia/reperfusion injury in rat kidneys
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Journal Article
Curcumin protects against ischemia/reperfusion injury in rat kidneys
2008
Overview
Objectives
Renal ischemia followed by reperfusion leads to acute renal failure in both native kidneys and renal allograft. We investigated the effect of curcumin on ischemia-reperfusion (I/R) injury and the antioxidant effects of curcumin in rats.
Methods
Thirty rats were randomly divided into five experimental groups (control, sham, curcumin, I/R and I/R + curcumin,
n
= 6 each). Curcumin was administered (200 mg kg
−1
) orally to curcumin and I/R + curcumin groups for 7 days. Then, the rats were subjected to bilateral renal ischemia for 45 min and followed by reperfusion for 24 h. All rats were killed and kidney function tests, serum and tissue nitric oxide (NO), protein carbonyl (PC), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels were determined. Histopathological examinations were also performed.
Results
Curcumin significantly improved the urea and cystatin C levels in I/R + curcumin group compared to I/R group (
p
< 0.05). Reduction of serum GSH-Px was significantly improved by curcumin (
p
< 0.001), but SOD enzyme activity did not alter (
p
> 0.05). Treatment with curcumin also resulted in significant reduction in serum and tissue MDA, NO and PC and for tissue that were increased by renal I/R injury (
p
< 0.001 for serum and
p
< 0.05 for tissue, respectively). In histological examination, the rats treated with curcumin had nearly normal morphology of the kidney.
Conclusions
Based on our results, it can be concluded that curcumin protects the kidneys against I/R injury via its antioxidant effects.
Publisher
Springer-Verlag,Springer,Springer Nature B.V
Subject
/ Animals
/ Biological and medical sciences
/ Curcumin - administration & dosage
/ Enzyme Inhibitors - administration & dosage
/ Enzyme Inhibitors - therapeutic use
/ Kidney Diseases - metabolism
/ Kidney Diseases - prevention & control
/ Male
/ Medicine
/ Nephrology. Urinary tract diseases
/ Oncology
/ Rats
/ Reperfusion Injury - prevention & control
/ Urology
