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Incidence, management, and outcome of incidental gallbladder carcinoma: analysis of the database of the Swiss association of laparoscopic and thoracoscopic surgery
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Incidence, management, and outcome of incidental gallbladder carcinoma: analysis of the database of the Swiss association of laparoscopic and thoracoscopic surgery
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Incidence, management, and outcome of incidental gallbladder carcinoma: analysis of the database of the Swiss association of laparoscopic and thoracoscopic surgery
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Journal Article
Incidence, management, and outcome of incidental gallbladder carcinoma: analysis of the database of the Swiss association of laparoscopic and thoracoscopic surgery
2010
Overview
Background
Little is known about the long-term survival of patients with incidental gallbladder carcinoma (IGBC). The role of radical resection for this disease is discussed controversially in the literature. We present the long-term survival and the results of re-resection versus simple cholecystectomy of the database of the Swiss Association for Laparoscopic and Thoracoscopic Surgery (SALTS) from 1994 to 2004.
Methods
Eighty-nine patients with histologically confirmed carcinoma of the gallbladder were identified out of 30,960 patients undergoing laparoscopic cholecystectomy. Sixty-nine patients were included in our study. Long-term survival by different T-stage and comparison of patients with extended resection versus simple cholecystectomy were calculated using the log-rank test. The time-to-event data are demonstrated by Kaplan–Meier curves.
Results
The overall incidence of IGBC in patients who underwent laparoscopic cholecystectomy was 0.28% (89 of 30,960). Fifty patients underwent simple cholecystectomy [
n
= 2: carcinoma in situ (CIS);
n
= 2: pT1a;
n
= 10: pT1b;
n
= 23: pT2;
n
= 8: pT3;
n
= 5: pT4], whereas extended resection was performed in 19 cases (
n
= 2: pT1b;
n
= 11: pT2;
n
= 6: pT3). The comparison of simple cholecystectomy versus extended re-resection of the gallbladder bed and regional lymph node resections showed a significant benefit in overall survival for the pT2 and pT3 group (
p
< 0.05). The pT1b group showed no significant benefit in overall survival (
p
= 0.34).
Conclusion
IGBC has a low incidence (0.28%). We present a large study of patients with IGBC, comparing the overall survival by different histological findings. We observed a significant benefit for the group with pT2 and pT3. Therefore we recommend extended resection of the gallbladder bed and the regional lymph nodes for patient with incidental histologically confirmed pT2 and pT3 carcinoma of the gallbladder after performance of laparoscopic cholecystectomy. For patients with pT1b stage no recommendations can be given based on this study.
Publisher
Springer-Verlag,Springer,Springer Nature B.V
Subject
/ Aged
/ Biological and medical sciences
/ Cancer
/ Carcinoma in Situ - epidemiology
/ Carcinoma in Situ - pathology
/ Cholecystectomy, Laparoscopic - methods
/ Female
/ Gallbladder Neoplasms - epidemiology
/ Gallbladder Neoplasms - pathology
/ Gallbladder Neoplasms - surgery
/ Humans
/ Investigative techniques, diagnostic techniques (general aspects)
/ Male
/ Medicine
/ Surgery
