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Ubiquitin‐specific peptidase 24 accelerates aerobic glycolysis and tumor progression in gastric carcinoma through stabilizing PLK1 to activate NOTCH1
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Ubiquitin‐specific peptidase 24 accelerates aerobic glycolysis and tumor progression in gastric carcinoma through stabilizing PLK1 to activate NOTCH1
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Journal Article
Ubiquitin‐specific peptidase 24 accelerates aerobic glycolysis and tumor progression in gastric carcinoma through stabilizing PLK1 to activate NOTCH1
2023
Overview
Ubiquitin‐specific peptidase 24 (USP24), a member of the deubiquitinase family, plays an important role in tumor regulation. However, the role of USP24 in gastric cancer (GC) is unknown. The aim of our study was to explore the role of USP24 in GC to seek new therapeutic targets for GC. TCGA analysis showed that USP24 was upregulated in GC patients, and its high expression levels were associated with poor prognosis. It was found that overexpressed USP24 promoted GC cell proliferation and abnormal glycolysis. Further analysis and study showed that USP24 could promote the stability and increase the expression of oncogene PLK1. Knocking down USP24 can reduce the stability of PLK1 to reduce Notch 1 activity, thus inhibiting GC glycolysis, proliferation, and other processes and alleviating tumor progression. Knocking down USP24 can inhibit GC progression. In conclusion, USP24 was upregulated in GC and promoted the growth and glycolysis of GC cells, the mechanism of which was related to the deubiquitination of PLK1 and the increase of its stability. Silencing USP24 inhibited the GC process. This study suggests that the USP24/PLK1/Notch 1 axis may be a novel therapeutic target for gastric cancer. Our study found that USP24 is highly expressed in GC, which is an indicator of the prognosis of GC patients. This is because USP24 promotes glycolysis of GC cells by upregulating PLK1 and activating the Notch signaling pathway, thus promoting the progress of GC, which may provide a basis for the treatment of GC and a new treatment option.
Publisher
John Wiley & Sons, Inc,John Wiley and Sons Inc
Subject
/ Cell Proliferation - genetics
/ Gene Expression Regulation, Neoplastic
/ Glucose
/ Humans
/ Kinases
/ Notch
/ Original
/ Plasmids
/ Proteins
/ Receptor, Notch1 - metabolism
/ Stomach Neoplasms - genetics
/ Tumors
/ ubiquitin specific peptidase 24
/ Ubiquitin Thiolesterase - metabolism
