Asset Details
Do you wish to reserve the book?
Gender-dependent cancer-specific survival following radical cystectomy
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Gender-dependent cancer-specific survival following radical cystectomy
Do you wish to request the book?
Gender-dependent cancer-specific survival following radical cystectomy
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Gender-dependent cancer-specific survival following radical cystectomy
2012
Overview
Objective
To assess the impact of detailed clinical and histopathological criteria on gender-dependent cancer-specific survival (CSS) in a large consecutive series of patients following radical cystectomy (RCE) for muscle-invasive bladder cancer (MIBC).
Patients and methods
Between 1992 and 2007, 388 men and 133 women (25.5%) underwent RCE for MIBC. A prospectively maintained database was analysed retrospectively. Uni- and multivariable Cox-regression analyses calculated the impact of detailed clinical and histopathological criteria on CSS. Median follow-up was 59 months (2–162).
Results
Among clinical and histopathological parameters, only type of urinary diversion differed between men and women. In univariable analysis, CSS did not differ between genders. In multivariable Cox-regression analysis, advanced pT-stage (HR = 2.12;
P
< 0.001), lymphovascular invasion (LVI) (HR = 3.47;
P
< 0.001), time interval between diagnosis of MIBC and RCE exceeding 90 days (HR = 2.07;
P
< 0.001) and female gender (HR = 1.35;
P
= 0.048) were related to reduced CSS. In separate multivariable Cox-models for time period of surgery between 1992 an 1999 (HR = 1.52;
P
= 0.050), age ≤55 years (HR = 3.00;
P
= 0.022), presence of LVI (HR = 1.45;
P
= 0.031) and female gender were associated with independent reduced CSS.
Conclusion
Established clinical and histopathological parameters do not differ significantly between both genders in the present series. Reduced CSS in women is present in historic cohorts possibly suggesting improvement in management over the last years. In particular, female gender has a significant negative impact on CSS in patients younger of age and with positive LVI status possibly suggesting different clinical phenotypes.
Publisher
Springer-Verlag,Springer,Springer Nature B.V
Subject
/ Biological and medical sciences
/ Carcinoma, Transitional Cell - mortality
/ Carcinoma, Transitional Cell - pathology
/ Carcinoma, Transitional Cell - surgery
/ Female
/ Humans
/ Male
/ Medicine
/ Nephrology. Urinary tract diseases
/ Oncology
/ Tumors of the urinary system
/ Urinary Bladder Neoplasms - mortality
/ Urinary Bladder Neoplasms - pathology
/ Urinary Bladder Neoplasms - surgery
/ Urinary Diversion - mortality
/ Urinary system involvement in other diseases. Miscellaneous
/ Urinary tract. Prostate gland
/ Urology
