Journal Article

Analysis of Connectome Graphs Based on Boundary Scale

Díaz-del-Río, Fernando, Real, Pedro, Moron-Fernández, María José, Monterroso Muñoz, Alberto, Marinozzi, Franco, Bini, Fabiano, Molina-Abril, Helena, Amedeo, Ludovica Maria

2023

Overview

The purpose of this work is to advance in the computational study of connectome graphs from a topological point of view. Specifically, starting from a sequence of hypergraphs associated to a brain graph (obtained using the Boundary Scale model, BS2), we analyze the resulting scale-space representation using classical topological features, such as Betti numbers and average node and edge degrees. In this way, the topological information that can be extracted from the original graph is substantially enriched, thus providing an insightful description of the graph from a clinical perspective. To assess the qualitative and quantitative topological information gain of the BS2 model, we carried out an empirical analysis of neuroimaging data using a dataset that contains the connectomes of 96 healthy subjects, 52 women and 44 men, generated from MRI scans in the Human Connectome Project. The results obtained shed light on the differences between these two classes of subjects in terms of neural connectivity.

• Publisher: MDPI AG,MDPI
• Subject: Betti numbers / Brain - diagnostic imaging / Brain research / Communication / connectome / Connectome - methods / Datasets / Female / Graphs / Healthy Volunteers / Humans / hypergraph theory / Magnetic Resonance Imaging - methods / Male / Neuroimaging / Scale models / topological scale