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miRNAs： novel regulators of autoimmunity-mediated pancreatic β-cell destruction in type 1 diabetes
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miRNAs： novel regulators of autoimmunity-mediated pancreatic β-cell destruction in type 1 diabetes
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Journal Article
miRNAs： novel regulators of autoimmunity-mediated pancreatic β-cell destruction in type 1 diabetes
2017
Overview
MicroRNAs （miRNAs） are a series of conserved, short, non-coding RNAs that modulate gene expression in a posttranscriptional manner, miRNAs are involved in almost every physiological and pathological process. Type 1 diabetes （TID） is an autoimmune disease that is the result of selective destruction of pancreatic p-cells driven by the immune system, miRNAs are also important participants in TID pathogenesis. Herein, we review the most recent data on the potential involvement of miRNAs in TID. Specifically, we focus on two aspects： the roles of miRNAs in maintaining immune homeostasis and regulating β-cell survival and/or functions in TID. We also discuss circulating miRNAs as potent biomarkers for the diagnosis and prediction of TID and investigate potential therapeutic approaches for this disease.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Biomedical and Life Sciences
/ Cells
/ Diabetes
/ Diabetes mellitus (insulin dependent)
/ Diabetes Mellitus, Type 1 - genetics
/ Disease
/ Humans
/ Insulin-Secreting Cells - physiology
/ miRNA
/ miRNAs
/ Pancreas
/ Review
/ Vaccine
/ β细胞
/ 介导
/ 患者
/ 糖尿病
/ 胰腺
/ 自身免疫性疾病
/ 调控基因表达
